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Completed

NCT Number: NCT02826720

Is There a Relationship Between Hyperlipidemia and Periodontitis?

The aim of present study is to investigate any relationship between hyperlipidemia and periodontal disease regarding the periodontal parameters and plasma lipid parameters, along with age, gender, brushing habit, body mass index, dietary habit, physical activity, alcohol consumption.

In this cross sectional study, a total of 160 individuals were divided into two groups based on their metabolic status: hyperlipidemic group (n=97) and normolipidemic group (n=63). Plaque index, gingival index, bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL) clinical parameters and community periodontal index of treatment needs (CPITN) scores were measured. Triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) levels had been determined previously during individuals routine systemic examinations. Daily brushing habits and interdental cleaning together with dietary habits, alcohol consumption and physical activity levels were also recorded.

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Key information

Conditions

Hyperlipidemia, Periodontal Disease Dyslipidemias Hyperlipidemias Lipid Metabolism Disorders Metabolic Diseases Mouth Diseases Nutritional and Metabolic Diseases Periodontal Diseases Stomatognathic Diseases

Age range

35 year–65 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects having no periodontal treatment within previous 6 months,
  • number of natural teeth ≥ 10,
  • no history of cancer and systemic disease that affects lipid levels or periodontium,
  • no history of medical treatment for hyperlipidemia, BMI< 30 kg/m2,
  • no pregnancy,
  • no history of systemic antibiotic treatment within previous 3 months,
  • no smoking.

Exclusion criteria

  • patients with history of systemic disease that affects lipid metabolism or periodontal disease
  • history of medical treatment for hyperlipidemia
  • pregnancy, lactation or hormone replacement therapy at the time of study
  • use of any other drug known to affect lipid metabolism or periodontal disease
  • systemic infection or any history of systemic antibiotic treatment in previous 3 months
  • smokers as well as ex-smokers

Treatment and study plan

No intervention was applied

Other

No intervention was applied

Primary outcomes

  1. Triglyceride (TG)

    Time frame: day 0

    Subjects with plasma TG or TC levels > 200 mg/dl and LDL-C levels > 130 mg/dl were included in the hyperlipidemic group, while the normolipidemic group comprised of patients with plasma TG or TC levels below the aforementioned limits

  2. Total cholesterol (TC)

    Time frame: day 0

    Subjects with plasma TG or TC levels > 200 mg/dl and LDL-C levels > 130 mg/dl were included in the hyperlipidemic group, while the normolipidemic group comprised of patients with plasma TG or TC levels below the aforementioned limits

  3. Low density lipoprotein cholesterol (LDL-C)

    Time frame: day 0

    Subjects with plasma TG or TC levels > 200 mg/dl and LDL-C levels > 130 mg/dl were included in the hyperlipidemic group, while the normolipidemic group comprised of patients with plasma TG or TC levels below the aforementioned limits

Secondary outcomes

  1. Plaque index

    Time frame: day 0

    The measurement of the state of oral hygiene based on recording dental plaque accumulation

  2. Gingival index

    Time frame: day 0

    An assessment level of gingival health and inflammation

  3. Bleeding on probing

    Time frame: day 0

    A sign of gingival inflammation were assessed on the buccal, lingual, mesial and distal sites of each tooth

  4. Probing depth

    Time frame: day 0

    The distance from the gingival margin to bottom of the pocket with using 0.5 mm diameter periodontal probe at mesiobuccal, midbuccal, distobuccal, distolingual, midlingual and mesiolingual sites of each tooth

  5. Clinical attachment level

    Time frame: day 0

    The distance between the cemento-enamel junction and bottom of the pocket

  6. Community Periodontal Index of Treatment Needs score

    Time frame: day 0

    These scores are used to represent healthy periodontium, bleeding after probing, dental calculus detected by probing, 4-5 mm deep pockets and deep pockets ≥ 6 mm, respectively.

Sponsors and collaborators

Lead sponsor

Marmara University

Other

Registry information

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Jul 11, 2016
Registry last updated
Jul 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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