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Completed

NCT Number: NCT02733549

Is The Sudden Onset of Dizziness A Symptom of Acute Liver Dysfunction?

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of liver function tests for patients with SOD in the ED, and a cost analysis of liver function tests.

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Key information

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Adiyaman University Research Hospital

Adıyaman, Central, 02000, Turkey (Türkiye)

About this study

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. The diagnosis of acute liver dysfunction (ALD) can usually be made by initial symptoms, physical examination, and biochemical tests, including liver function tests (LFTs) with high sensitivity and specificity. LFTs include albumin, bilirubin, coagulation factors (Activated Partial Thromboplastin Time (aPTT) and International Normalized Ratio (INR)), and liver enzymes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), and y-glutamyl transpeptidase (GGT), which are marker of hepatic damage. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of LFTs for patients with SOD in the ED, and a cost analysis of LFTs.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients who were experiencing sudden onset dizziness of unknown etiology for the first time were included in the study

Exclusion criteria

  • Patients with a history of chronic diseases such as any liver disease,diabetes mellitus, hypertension,congestive heart failure, hepatitis B or C infection
  • Patients with any central dizziness attacks
  • Patients with hemodynamically unstable and emesis;
  • Patients receiving drugs that could affect liver function tests, such as, acetaminophen, antibiotics, oral contraceptives, antihypertensive drugs (e.g., angiotensinconverting enzyme inhibitors), or hormones (e.g.,estrogen)
  • Patients who was experienced dizziness with systemic diseases
  • Patients with any neurological disorders
  • Patient who do not want to participate in the study

Treatment and study plan

LFTs

Other

A single 5-ml peripheral venous blood sample was collected from each participant.

Serum ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, and albumin level, Platelet count, INR and aPTT were analyzed.

Other names: liver function tests

Primary outcomes

  1. LFTs serum levels by biochemical method ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, albumin, INR, aPTT, and Platelet count (PC)

    Time frame: 5 months

    The serum levels of LFTs will obtained by the laboratory analysis of blood samples of each participant.

Secondary outcomes

  1. The cost calculation for the LFTs

    Time frame: 5 months

    The cost for the LFTs will be calculated with financial data in invoices which will obtained from the hospital invoicing service.

Sponsors and collaborators

Lead sponsor

Adiyaman University Research Hospital

Other

Registry information

Official study title

Is The Sudden Onset of Dizziness A Symptom of Acute Liver Dysfunction?An ED Study

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Apr 11, 2016
Registry last updated
Apr 12, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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