Is Saxenda® a Viable Treatment of Obese Patients in Forensic Psychiatry?

Inclusion criteria

• Informed oral and written consent
• Diagnosed with a mental illness according to the criteria of ICD10
• Hospitalised at a forensic psychiatric department during the full inclusion period
• Age 18 years to 65 years (both included)
• BMI ≥27 kg/m2 with one or more weight-related comorbidities (sleep apnea, hypertension (BT ≥ 140/90 mmHg with no antihypertensive treatment. BT ≥ 130/80 mmHg with antihypertensive treatment), dyslipidaemia (LDL cholesterol ≥ 3 mmol/L), pre-diabetes (HbA1c 39-47 mmol/mol) or type 2 diabetes (HbA1c ≥ 48 mmol/mol)) or BMI ≥30 kg/m2

Exclusion criteria

• Any use of coercive measures according to the Danish law for Mental Health/Psykiatriloven (as defined in "Informationsbekendtgørelsen § 10").
• Fertile females of child-bearing potential who are pregnant, breast-feeding or have the intention of becoming pregnant
• Women who are not willing to use an adequate contraceptive considered as highly effective (IUD or hormonal contraception during the full length of the study
• Impaired hepatic function (plasma liver transaminases >2 times the upper normal limit)
• Impaired renal function (serum creatinine >150 μmol/l and/or macroalbuminuria)
• Impaired pancreatic function (acute or chronic pancreatitis and/or plasma amylase >2 times the upper normal limit)
• Cardiac problems defined as decompensated heart failure (NYHA class III/IV), unstable angina pectoris and/or myocardial infarction within the last 12 months
• Hypertension with systolic blood pressure >180 mmHg or diastolic blood pressure >100 mmHg
• Any condition that the investigator feels would interfere with trial participation
• Use of weight-lowering pharmacotherapy within the preceding 3 months
• Type 1 diabetes
• Patients treated with insulin
• Patients treated with other GLP-1 receptor agonist medicines
• Known allergy to liraglutide or any of the ingredients in Saxenda®