Is Low Flow Anaesthesia Feasible?

Although low-flow anaesthesia (LFA) has been described for many years and its benefits are known, its clinical use has been limited. Concerns about the risk of hypoxia contributed to this situation. Although the risk of hypoxia is almost prevented with advanced anaesthesia machines, the use of LFA has not reached the desired levels. However, in recent years, as adverse developments related to climate change have started to affect us all, LFA has started to be on the agenda of anaesthetists again. In this study, our aim is to examine the feasibility of its clinical use in order to popularise the use of LFA.

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Key information

Conditions

Anesthesia

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Inonu Univercity

Malatya, 44280, Turkey (Türkiye)

About this study

ASA 1-2 patients who will undergo elective surgery under general anaesthesia in 38 operating rooms of Inonu University Faculty of Medicine will be prospectively recruited for 3 months (May-June-July). Emergency cases, patients under the age of 18 and over 65, laparoscopic surgeries, heart-lung surgeries that may impair oxygenation will not be included in the study.

Inhaler anaesthesia will be administered after anaesthesia induction and tracheal intubation. Fresh gas flow (FGF) will be determined as 1 l/min, MAC=1, FiO2=40% with target controlled automatic gas control mode (AGC). FGF will be decreased to 0.5 l/min 10 minutes after surgical incision, if successful, it will be decreased to 0.3 l/min 10 minutes later and it will be checked whether it is successful. The study will be terminated and FGF will be increased to 1 l/min again.

Demographic data of the patients and FGF levels that can provide FiO2=40% will be recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients undergoing surgery under general anaesthesia

Exclusion criteria

Emergency operations
Previously diagnosed heart, lung, liver and kidney disease
Surgeries that may impair oxygenation (laparoscopic, Heart, Lung surgeries)

Treatment and study plan

Primary outcomes

Feasibility of Low Flow Anaesthesia

Time frame: The measurement will start 10 minutes after the surgical incision and end 20 minutes later

To determine the lowest amount of fresh gas flow, most suitable for the patient and, which can provide FiO2=40% level

Secondary outcomes

Factors affecting oxygen consumption

Time frame: The measurement will start 10 minutes after the surgical incision and end 20 minutes later

To find out which of the patient's physical characteristics that affect oxygen consumption may be determinant.

Sponsors and collaborators

Lead sponsor

Inonu University

Other

Registry information

Official study title

Low Flow Anaesthesia is Good But Feasible?

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Apr 29, 2024
Registry last updated: Oct 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed