Is It So Hard To Predict Complicated Diverticulitis?

Objective: Acute diverticulitis (AD) is a frequent cause of abdominal pain leading to emergency department visits. Many biomarkers have been identified to predict the risk of developing complicated diverticulitis. In our study, we aimed to reveal the sensitivity of these biomarkers in order to better differentiate uncomplicated AD from complicated ones.

Methods: 101 patients who were diagnosed with AD in the emergency outpatient clinic between 2018 and 2022, registered in the database of our hospital, were evaluated retrospectively. Demographic data of the patients and laboratory results at the time of admission were evaluated. Patients were classified as having non-complicated (Group I) or complicated diverticulitis (Group II) based on the World Society of Emergency Surgery (WSES) criteria. Laboratory values at admission, including albumin, white blood cell count (WBC), C-reactive protein (CRP), neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR), were evaluated.

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Key information

Conditions

Diverticulitis Digestive System Diseases Disease Attributes Diverticular Diseases Emergencies Gastroenteritis Gastrointestinal Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Haydarpasa Numune Research and Training Hospital

Istanbul, 34668, Turkey (Türkiye)

About this study

101 patients who were diagnosed with AD in the emergency outpatient clinic between 2018 and 2022, registered in the database of our hospital, were evaluated retrospectively. Demographic data of the patients and laboratory results at the time of admission were evaluated. Patients were classified as having non-complicated (Group I) or complicated diverticulitis (Group II) based on the World Society of Emergency Surgery (WSES) criteria. Laboratory values at admission, including albumin, white blood cell count (WBC), C-reactive protein (CRP), neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR), were evaluated.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Admission to the Haydarpaşa Numune Training and Research Hospital General Surgery Clinic
First episode of acute diverticulitis
Diagnosis confirmed by contrast-enhanced abdominal computed tomography (CT)
Admission between 2018 and 2022
Retrospective identification from the hospital registry system

Exclusion criteria

Recurrent episodes of diverticulitis
History of prior colorectal surgery
Symptom duration longer than 7 days before admission
Inconsistent physical examination findings with laboratory or imaging results
Age under 18 years
Pathologically confirmed malignancy

Treatment and study plan

Primary outcomes

Number of participants diagnosed with complicated acute diverticulitis according to the WSES classification

Time frame: Time frame is the length of stay usually between 1-14 days

Acute diverticulitis severity will be classified using the World Society of Emergency Surgery (WSES) diverticulitis grading system based on contrast-enhanced abdominal computed tomography (CT) findings at the time of admission.

Patients will be categorized as having uncomplicated diverticulitis (WSES grades 1a and 1b) or complicated diverticulitis (WSES grades 2, 3, and 4). The primary outcome is the number of participants diagnosed with complicated diverticulitis.

Sponsors and collaborators

Lead sponsor

Haydarpasa Numune Training and Research Hospital

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Jan 7, 2026
Registry last updated: Jan 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed