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Completed

NCT Number: NCT02111733

Is High Sensibility Troponins a Dialysable Marker in Hemodialysis Patients and Does it Have Prognostic Value?

Evaluation of High sensibility troponin levels modification by hemodialysis in terminal renal failure patient at Sherbrooke University Hospital Center as determined by serial measurements. Verification of potential effects of these levels and their variation as predictors of cardiovascular outcomes and events at 6 and 12 months.

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Key information

Conditions

Renal Failure Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada

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About this study

Recruiting of hemodialysis patients of the nephrology renal supplementation clinics at Sherbrooke University Hospital Center to measure three blood level of high-sensibility troponins before and after standard dialysis. Verification on the variation of these levels after dialysis. Follow-up at 6 and 12 months of the patient for Cardiovascular events and death and verification of a possible predictive value of troponin blood levels for these events.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • over 50 years, no symptoms, over 1 months of hemodialysis

Exclusion criteria

  • 1 or more in the last month; Acute coronary syndrome, Heart failure decompensated, Myo or Pericarditis, Pulmonary embolism, Sepsis/shock, Stroke or transient ischemic attack, Malignant high blood pressure, Arrythmia, electrical cardio-version, major trauma, significant burnings (>25%), Chemotherapy, Cardiovascular surgery, percutaneous angio-intervention,
  • Chronic systemic disease (sarcoidosis, amyloidosis, LED, Etc.)

Treatment and study plan

Hs-TNT dosage

Other

Bloodwork before and after hemodialysis for high sensibility troponins T blood level

Primary outcomes

  1. High sensibility troponins T blood level variation

    Time frame: 1 week

    Verification of high sensibility troponins T blood after classical hemodialysis compared to pre-treatment levels.

Secondary outcomes

  1. Prognostic value of high sensibility troponins T blood level variation

    Time frame: at 6 and 12 months

    Evaluation of a potential prognosis value of high sensibility troponins T blood levels and its variation after hemodialysis.

Sponsors and collaborators

Lead sponsor

Université de Sherbrooke

Other

Registry information

Acronym: TnT-HD

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Apr 11, 2014
Registry last updated
Apr 11, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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