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OpenTrials
Completed

NCT Number: NCT04427878

Is Adipose Tissue a Reservoir for SARS-Cov2 Spread in Covid-19 Patients?

Resident cells of human adipose tissue express ACE2 and DPP4, receptors for SARS-Cov2. The hypothesis is that the virus may enter and spread in fat depots.

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Key information

Conditions

COVID-19 Patients

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Nice

Nice, 06000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female ≥ 18 years old
  • Patients testing positive for Covid19
  • Patients affiliated to social security
  • Signing of free and informed consent

Exclusion criteria

  • Vulnerable persons (- minors,
  • adults under guardianship or curatorship,
  • pregnant women,
  • persons deprived of their liberty,
  • persons who do not master the French language)

Treatment and study plan

biopsies of subcutaneous adipose tissue

Procedure

Two 4mm punch biopsies of subcutaneous abdominal or thight adipose tissue

Primary outcomes

  1. The presence of SARS-CoV2 in adipose tissue of Covid19 patients

    Time frame: Day 0

    RT-qPCR for SARS-Cov-2 from RNAs and by immunodetection

Secondary outcomes

  1. The expression of inflammatory cytokines in adipose tissue of Covid19 patients

    Time frame: Day 0

    RT-qPCR for IL6

  2. The expression of inflammatory cytokines in adipose tissue of Covid19 patients

    Time frame: Day 0

    RT-qPCR for IL1

  3. The expression of inflammatory cytokines in adipose tissue of Covid19 patients

    Time frame: Day 0

    RT-qPCR for TNFa

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Is Adipose Tissue a Reservoir for SARS-Cov2 Spread?

Acronym: TA/SARS-Cov2

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jun 11, 2020
Registry last updated
Jun 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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