Skip to main content
OpenTrials
Completed

NCT Number: NCT01163877

Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma

The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Malaria, Falciparum Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Helminthiasis Hookworm Infections Infections Malaria Male Urogenital Diseases Mosquito-Borne Diseases Nematode Infections Parasitic Diseases Protozoan Infections Schistosoma Haematobium Schistosomiasis Schistosomiasis haematobia Secernentea Infections Strongylida Infections Trematode Infections Urinary Tract Infections Urogenital Diseases Urologic Diseases Vector Borne Diseases

Age range

12 year–16 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Taabo Cité Hospital

Taabo, Côte d’Ivoire

About this study

The aim of the study is to determine how iron metabolism in subjects with infectious diseases (malaria, hookworm or S. haematobium) differs while infected and after treatment, i.e. the same individuals will be restudied while free of infection.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children aged 12 to 16 years
  • Body weight > 30 kg
  • no chronic medical illnesses
  • no intake of vitamin/mineral supplements 2 weeks before the study and until the last blood drawing
  • For each of the 4 arms the respective disease needs to be present (symptomatic malaria, asymptomatic malaria, hookworm infection, S. haematobium infection) without any other concurrent infection

Exclusion criteria

-

Treatment and study plan

Fe-57 orally, Fe-58 intravenously

Dietary Supplement

Subjects will receive a test drink containing 3 mg Fe-57 in the form of labelled FeSO4 followed by 1 ml of an aqueous solution containing 50 μg Fe-58 as iron citrate.

Primary outcomes

  1. Isotope absorption into blood stream

    Time frame: Day 15

  2. Isotope absorption into blood stream

    Time frame: Day 43

Secondary outcomes

  1. Isotope incorporation into erythrocytes

    Time frame: Day 15

  2. Biochemical parameters of iron status and infection

    Time frame: Day 1

  3. Biochemical parameters of iron status and infection

    Time frame: Day 15

  4. Biochemical parameters of iron status and infection

    Time frame: Day 29

  5. Biochemical parameters of iron status and infection

    Time frame: Day 43

  6. Isotope incorporation into erythrocytes

    Time frame: Day 43

Sponsors and collaborators

Lead sponsor

Swiss Federal Institute of Technology

Other

Registry information

Official study title

Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma.

Important dates

Study start
2010
Primary completion
2013
Study completion
2013
First posted
Jul 16, 2010
Registry last updated
Oct 14, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.