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Completed

NCT Number: NCT04079322

Iron Absorption and Exercise

Iron is a nutritionally essential mineral required for optimal physical and cognitive performance. Endurance exercise often leads to declines in iron status; however, the reason for the decline is not known. The primary objective of the proposed study is to determine the effects of an acute bout of strenuous endurance exercise on iron absorption and status and markers of inflammation in human volunteers. The investigators hypothesize that an acute bout of strenuous endurance exercise, compared to rest, will reduce iron absorption, resulting in diminished iron status, and that reduced iron absorption will be negatively associated with markers of inflammation. A secondary objective is to monitor iron status throughout a season of competition.

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Key information

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Florida State University

Tallahassee, Florida, 32306, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Members of the Florida State University Cross Country team
  • Refrain from using any pain-relievers (e.g., acetaminophen, nonsteroidal anti-inflammatory drugs such as aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product on the 2 study days
  • Refrain from using vitamin or mineral supplements on the study days

Exclusion criteria

  • Musculoskeletal injury that compromise the ability to exercise

Treatment and study plan

Meal

Other

Participants will consume a meal containing a stable iron isotope following exercise or rest.

Primary outcomes

  1. Change in fractional iron absorption

    Time frame: Red blood cells collected on day 0 and day 14

    Stable iron isotopes

Secondary outcomes

  1. Change in concentration of ferritin in ng/mL

    Time frame: Day 0 and day 14

    Blood measure

  2. Change in concentration of soluble transferrin receptor in nmol/L

    Time frame: Day 0 and day 14

    Blood measure

  3. Change in concentration of hemoglobin in g/L

    Time frame: Day 0 and day 14

    Blood measure

  4. Change in concentration of hematocrit as %

    Time frame: Day 0 and day 14

    Blood measure

  5. Change in concentration of hepcidin in ng/mL

    Time frame: Day 0 and day 14

    Blood measure

  6. Change in concentration of IL-6 in pg/mL

    Time frame: Day 0 and day 14

    Blood measure

Sponsors and collaborators

Lead sponsor

Florida State University

Other

Registry information

Official study title

Fractional Iron Absorption in Response to an Acute Bout of Exercise

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Sep 6, 2019
Registry last updated
Feb 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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