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Completed

NCT Number: NCT02881892

Iplasma IL6, Procalcitonin and VEGF and Dialysate Level in CAPD Patients

The aim of study was to evaluated the correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.

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Key information

Conditions

Chronic Kidney Disease Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Renal Unit, BMA Medical College and Vajira Hospital

Bangkok, 10300, Thailand

About this study

This cross -sectional study measured IL-6, procalcitonin and VEGF level in plasma and overnight effluent. PSTR of small solutes was evaluated by standard peritoneal equilibration test (standard PET). Weekly Kt/V and creatinine clearance (CCr ) were evaluated in all patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Stable CAPD patients without previous history of peritonitis

Exclusion criteria

  • HIV
  • Other infections, tuberculosis or on immunosuppressive drugs,
  • Autoimmune disease,
  • Cancer
  • Diagnosis of permanent ultrafiltration failure .

Treatment and study plan

Measure plasma and dialysate level of IL-6, procalcitonin and VEGF

Other

correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.

Primary outcomes

  1. plasma level of VEGF, IL-6 and procalcitonin with the PSTR and dialysis adequacy in CAPD patients

    Time frame: 2 years

    measure in pg/ml

Secondary outcomes

  1. Cytokines in diabetic and non-diabetic group

    Time frame: 2 years

    All cytokines in plasma and blood

Sponsors and collaborators

Lead sponsor

Bangkok Metropolitan Administration Medical College and Vajira Hospital

Other Gov

Registry information

Official study title

Interleukin-6, Procalcitonin and Vascular Endothelial Growth Factor in Plasma and Dialysate Correlate With Peritoneal Solute Transport and Dialysis Adequacy in CAPD Patients

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Aug 29, 2016
Registry last updated
Aug 29, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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