IOS Parameters and PAP Titration Pressure in Obstructive Sleep Apnea

This prospective observational study aims to investigate whether impulse oscillometry (IOS)-a non-invasive lung function test-can help predict the specific pressure settings needed for positive airway pressure (PAP) therapy in patients with obstructive sleep apnea (OSA).

Currently, finding the optimal therapeutic pressure for OSA patients typically requires a titration process during sleep. This study explores if IOS parameters, which measure airway resistance and elasticity through small pressure oscillations during normal breathing, correlate with the final titration pressures (CPAP, EPAP, IPAP, and ΔP) determined by polysomnography.

Adult patients diagnosed with moderate-to-severe OSA (Apnea-Hypopnea Index ≥ 15) will undergo standard diagnostic sleep testing followed by IOS testing using the Vyaire Vyntus BodyBox® system. The researchers will evaluate whether these respiratory measurements can accurately predict required airway pressures and if they can help clinicians distinguish between patients who need Continuous Positive Airway Pressure (CPAP) versus Bilevel Positive Airway Pressure (BPAP) therapy.

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Key information

Conditions

Obstructive Sleep Apnea (OSA) Apnea Dyssomnias Microcephaly, Primary Autosomal Recessive, 6 Nervous System Diseases Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hatay Mustafa Kemal University

Antakya, Hatay, 31001, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults aged 18 to 80 years
Diagnosed with obstructive sleep apnea (OSA) by overnight polysomnography (PSG)
Apnea-hypopnea index (AHI) ≥ 15
Undergoing positive airway pressure (PAP) titration (CPAP or BPAP)
Able to perform impulse oscillometry (IOS) test
Provided written informed consent

Exclusion criteria

Central sleep apnea
Neuromuscular disease or restrictive lung disease
Recent upper airway infection (< 2 weeks)
Incomplete PSG or IOS data
Inability to cooperate with testing procedures

Treatment and study plan

Primary outcomes

Correlation between baseline impulse oscillometry (IOS) parameters (R5, X5, and Fres) and optimal CPAP pressure.

Time frame: From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks)

Evaluating the relationship between specific lung function parameters-specifically total airway resistance (R5), reactance (X5), and resonant frequency (Fres)-measured by a daytime IOS session, and the effective Continuous Positive Airway Pressure (CPAP) determined during the subsequent overnight titration study.

Secondary outcomes

Discriminative ability of IOS parameters for CPAP versus BPAP treatment allocation.

Time frame: From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks).

Assessing whether baseline impulse oscillometry parameters (R5, X5, Fres, AX) can predict if a patient will require Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (BPAP) therapy. This will be evaluated using the Area Under the Receiver Operating Characteristic (ROC) Curve.
Correlation between baseline IOS reactance parameters and bilevel pressure settings (IPAP/EPAP).

Time frame: From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks).

Assessing whether baseline impulse oscillometry parameters can predict the specific Inspiratory Positive Airway Pressure (IPAP) and Expiratory Positive Airway Pressure (EPAP) levels required for Bilevel Positive Airway Pressure (BPAP) therapy. This will be evaluated using the correlation coefficient.

Study contacts

Contact information is provided by the study sponsor or research team.

Kadir Burak Akgün, Assistant Professor

CONTACT

[email protected]

+905448127828

Sponsors and collaborators

Lead sponsor

Mustafa Kemal University

Other

Registry information

Official study title

Impulse Oscillometry for Prediction of PAP Titration Pressure in Obstructive Sleep Apnea (IOS-PAP Study)

Acronym: IOS-PAP

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2027
First posted: Apr 28, 2026
Registry last updated: Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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