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Completed

NCT Number: NCT04412980

Ionized Magnesium for Monitoring of Citrate-anticoagulated CVVHD

It has been reported in several studies that ionized hypomagnesemia is associated with higher morbidity and mortality rates. During continuous renal replacement therapy with regional citrate anticoagulation (CRRT-RCA), the loss of magnesium has been reported to not be covered by magnesium concentration in ordinary dialysis fluid. This may lead to ionized hypomagnesemia. However the incidence of ionized hypomagnesemia in patients requiring CRRT-RCA remains unclear and need to be estimated to determine if ionized magnesium monitoring could be of interest. This study aim to assess the incidence of ionized hypomagnesemia induced by CRRT-RCA.

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Key information

Conditions

Intensive Care Unit Syndrome

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Uhmontpellier

Montpellier, 34295, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Consecutive patients admitted to the ICU and requiring continuous renal replacement therapy with regional citrate anticoagulation
  • age > 18 ans

Exclusion criteria

  • Persons under protection
  • Paritcipation rejections

Treatment and study plan

Primary outcomes

  1. assess the systemic ionized magnesemia change after 24h of CRRTsystemic variations of iMg

    Time frame: Day 0 and Day 1

    assess the systemic ionized magnesemia change after 24h of CRRT wiith regional citrate anticoagulation

Secondary outcomes

  1. Proportion of patients with heart rhythm disturbances

    Time frame: 1 day

    Proportion of patients with heart rhythm disturbances

  2. Assessment of morbidity and mortality

    Time frame: 1 day

    Assessment of morbidity and mortality

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Collaborators

  • Novamedica Laboratories

Registry information

Official study title

Importance of Ionized Magnesium Measurement for Monitoring of Continuous Venovenous Haemodialysis With Citrate Anticoagulation

Acronym: MagiCC

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jun 2, 2020
Registry last updated
Nov 24, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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