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NCT Number: NCT07197632

ioMRI in the Surgery of Brain Metastases.

The study aims to improve the surgical treatment of brain metastases through the use of advanced imaging techniques. The investigators are examining how intraoperative MRI (iMRI) can aid surgeons in precisely locating and removing tumors, with the potential to enhance surgical outcomes and reduce the need for additional procedures. While iMRI offers the promise of better tumor visualization during surgery, it is also associated with longer surgical times and may carry the risk of increased complications. This study seeks to carefully evaluate these aspects to determine the overall benefits and challenges of iMRI in brain metastasis surgeries. The ultimate aim is to enhance treatment effectiveness and improve recovery and health outcomes for participants dealing with brain metastases.

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Key information

Conditions

Brain Metastases Brain Diseases Brain Neoplasms Central Nervous System Diseases Central Nervous System Neoplasms Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Neurosurgery, München University Hospital rechts der Isar (MRI)

Munich, 81675, Germany

Location status: Recruiting

Location contact

Maria Goldberg

CONTACT

[email protected]

+498941402151

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients for whom surgical resection of brain metastasis is indicated

Exclusion criteria

  • age < 18
  • 3T MRI contraindications

Treatment and study plan

Surgery with intraoperative MRI

Procedure

In this clinical study, we have the unique opportunity to utilize a 3 Tesla MRI intraoperatively during the surgical resection of brain metastases. This approach is distinctly different from standard procedures and offers several advantages. The use of a 3 Tesla MRI provides high-resolution imaging during surgery, offering unparalleled detail of brain structures and tumor boundaries. This level of imaging precision is typically not available in standard surgical procedures. Through real-time visualization, surgeons can better differentiate between tumor tissue and healthy brain tissue, potentially increasing the accuracy of tumor removal and minimizing damage to surrounding areas. Unlike conventional methods, this procedure allows for immediate intraoperative imaging feedback, enabling surgical teams to adjust their techniques dynamically

Primary outcomes

  1. Rate for complete resection

    Time frame: immediately after the surgery

    The postoperative MRI obtained within 72 hours after surgery will be analyzed to identify the rates of resection.

Secondary outcomes

  1. Complications

    Time frame: Perioperatively

    Hemorrhages, Ischemias, epileptic seizures, hydrocephalus, wound infection, Anesthesiological complications, neurological deficits

Other outcomes

  1. Overall survival

    Time frame: Through study completion, an average of 2 years

Study contacts

Contact information is provided by the study sponsor or research team.

Maria Goldberg

CONTACT

[email protected]

+498941402151

Sponsors and collaborators

Lead sponsor

Technical University of Munich

Other

Registry information

Official study title

Evaluation of the Efficacy and Safety of Intraoperative MRI in the Surgery of Brain Metastases.

Acronym: MET-MRI

Important dates

Study start
2025
Primary completion
2027
Study completion
2030
First posted
Sep 29, 2025
Registry last updated
May 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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