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NCT Number: NCT06623500

Iodine Nutrition Status and Clinical Characteristics of Thyroid Cancer

The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019，and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.

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Key information

Conditions

Thyroid Cancer Endocrine Gland Neoplasms Endocrine System Diseases Head and Neck Neoplasms Neoplasms Neoplasms by Site Thyroid Diseases Thyroid Neoplasms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Shandong Provincial Hospital

Jinan, Shandong, 250021, China

Location status: Recruiting

Location contact

Haiqing Zhang, doctor

CONTACT

[email protected]

（86）15168888303

Qingling Guo, doctor

CONTACT

[email protected]

13026575201

About this study

Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions for at least 5 years and diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age range: 18~65 years old, gender not limited;
  • Living in the selected region for at least 5 years;
  • Patients who underwent thyroid surgery at various research centers were pathologically diagnosed with thyroid cancer;
  • The clinical data （general information、surgical scope 、pathological report、utrasonic report, etc ）of the case is complete.

Exclusion criteria

  • Diagnosed as other types of cancer or thyroid metastatic cancer;
  • There are serious comorbidities such as heart, liver, and kidney diseases present;
  • Unable to follow up on prognostic information.

Treatment and study plan

Iodine excess

Dietary Supplement

Iodine excess areas: water iodine ≥100μg/L; or urinary iodine concentration (median urinary iodine levels in children aged 8-10 years old)≥300μg/L

Iodine suitable

Dietary Supplement

Iodine suitable areas：water iodine ≥40μg/L and ≤100μg/L; or urinary iodine concentration(median urinary iodine levels in children aged 8-10 years old) 100-199μg/L.

Primary outcomes

  1. Number of participants with recurrence

    Time frame: from enrollment to the final follow-up at 5 years

    Recurrence: diagnosed as the same type of thyroid cancer again by pathology

  2. Number of participants with distant metastasis

    Time frame: from enrollment to the final follow-up at 5 years

    Distant metastasis: Pathological confirmed thyroid cancer occurring outside the thyroid gland

  3. All-cause mortality

    Time frame: from enrollment to the final follow-up at 5 years

    The ratio of the total number of deaths caused by various reasons during the research period to the number of participants

Study contacts

Contact information is provided by the study sponsor or research team.

Qingling Guo

CONTACT

[email protected]

+86 0531-68776375

Sponsors and collaborators

Lead sponsor

Shandong Provincial Hospital

Other Gov

Registry information

Official study title

Prospective Cohort Study on Clinical Characteristics of Thyroid Cancer in Different Iodine Status Areas

Important dates

Study start
2012
Primary completion
2026
Study completion
2026
First posted
Oct 2, 2024
Registry last updated
Oct 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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