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OpenTrials
Completed

NCT Number: NCT03114267

Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis

Autoimmune diseases represent a heterogeneous group of pathologies whose etiopathogenic mechanisms are most often unknown. Autoimmune diseases are the leading cause of morbidity and mortality in young women and autoimmune thyroid diseases are the most common.

Viral infections are the main environmental factors suspected of triggering autoimmune diseases. Several viruses are certainly involved, all of which are possibly capable of triggering an autoimmune response. However, the precise identification of the viruses involved remains to be established.

It has been shown for the first time by the 2005 PHRC that enteroviral RNA is present in perioperative specimens of thyroid tissue. However, this case-control study did not show any difference between the thyroid group and the group other thyroid pathologies It has been recently published that Parvovirus is possibly involved in thyroiditis: the parvoviral genome is present in the thyroid tissue of Hashimoto thyroiditis operated and more precisely is present within the thyrocytes itself.

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Key information

Conditions

Autoimmune Diseases Chronic Lymphocytic Thyroiditis Endocrine System Diseases Hashimoto Disease Immune System Diseases Thyroid Diseases Thyroiditis Thyroiditis, Autoimmune

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Amiens Picardie

Amiens, Picardie, 80054, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients participating in PHRC 2005 "involvement of enteroviruses in TLC pathogenesis"
  • Inclusion of TLC: presence of a significant lymphocyte infiltrate within the thyroid parenchyma defined by the presence of clusters of more than 30 to 50 lymphocytes
  • Inclusion of controls: absence of significant lymphocyte infiltrate

Exclusion criteria

  • Persons refusing to participate in research

Treatment and study plan

Comparison of the prevalences of the parvovirus genome

Other

Comparison of the prevalences of the parvovirus genome between cases and controls and then of other viruses according to the results of parvoviruses and data from the literature

Primary outcomes

  1. Analysis of the viral genome by PCR carried out in the Virology department, Analysis of the presence of capsid protein

    Time frame: 1 day

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: Etude thyrovir

Important dates

Study start
2012
Primary completion
2015
Study completion
2015
First posted
Apr 14, 2017
Registry last updated
Apr 14, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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