Involvement of Monocytic B1 and B2 Receptors in Inflammation and Chronic Vascular Disease in Patients With Hereditary Bradykinetic Angioedema

Inclusion criteria

(patients):

• Patient with inherited bradykinic angioedema due to quantitative or qualitative C1-inhibitor deficiencies, regardless of the frequency or severity of seizures and regardless of their background treatment, with the following diagnostic criteria:

• C1-inhibitor rate <50% of normal
• Repeated episodes characteristic of bradykinic angioedema
• Hereditary nature of the disease.
• Person who read and understood the newsletter and signed the consent form
• Person affiliated with a social security scheme
• Effective contraception in women of childbearing age (negative pregnancy test). For postmenopausal women, a confirmatory diagnosis should be obtained (amenorrhea for at least 12 months before the inclusion visit).

Inclusion criteria

(volunteers):

• Person affiliated with a social security scheme
• Person who read and understood the newsletter and signed the consent form
• Effective contraception in women of childbearing age (negative pregnancy test). For postmenopausal women, a confirmation diagnosis should be obtained (amenorrhea for at least 12 months before the inclusion visit)

Exclusion criteria

(patients):

• Angioedema crisis less than 1 month old
• Chronic inflammatory disease such as rheumatoid arthritis or Crohn's disease.
• Acute infection in progress, with or without anti-infectious treatment
• Contraindication to the use of trinitrin:

• Hypersensitivity to nitrates or to any of the excipients
• shock, severe hypotension,
• obstructive cardiomyopathy,
• inferior court inferior myocardial infarction with right ventricular extension, except in case of evidence of left ventricular failure,
• intracranial hypertension,
• patient treated with sildenafil
• Pregnant or parturient or breastfeeding woman or lack of proven contraception
• Person deprived of liberty by an administrative or judicial decision or person placed under the protection of justice / sub-tutorship or curatorship
• Patient participating or having participated in another therapeutic trial within one week.

Exclusion criteria

(volunteers)

• Chronic inflammatory disease such as rheumatoid arthritis or Crohn's disease.
• Acute infection in progress, with or without anti-infectious treatment
• Contraindication to the use of trinitrin:

• Hypersensitivity to nitrates or to any of the excipients
• shock, severe hypotension,
• obstructive cardiomyopathy,
• inferior court inferior myocardial infarction with right ventricular extension, except in case of evidence of left ventricular failure,
• intracranial hypertension,
• patient treated with sildenafil
• Pregnant or parturient or breastfeeding woman or lack of proven contraception
• Person deprived of liberty by an administrative or judicial decision or person placed under the protection of justice / sub-tutorship or curatorship
• Person participating or having participated in another therapeutic trial within one week.