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OpenTrials
Completed

NCT Number: NCT00926692

Investigations Regarding B-cell Subsets in Humans

The aim of this research is to define the human equivalent of mouse B1 cells.

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Key information

Conditions

Healthy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Feinstein Institute for Medical Research

Manhasset, New York, 11030, United States

About this study

The specific aim of this research project is to define the human equivalent of mouse B1 cells. This will be done by evaluating IgM secretion, surface markers, functional characteristics, V gene usage, N-region addition, and phosphorylation status of intracellular proteins, gene expression, sequencing of immunoglobulin genes, determination of antigenic specificity, replication history, and response to different stimuli.

The goal of this project is to begin to the translation of decades of basic science research and research in the mouse model into the human system. It is believed that properly defining this B cell subset in humans will lead to better therapeutics, prognostics and prevention for a number of disease including infections, autoimmune disease, and cancer.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subject is considered by the physician to be a healthy adult.

Exclusion criteria

  • Subject is under the age of 18
  • Subject has an infection or is currently ill

Treatment and study plan

Blood Draw

Other

Subject will have blood draw.

Primary outcomes

  1. Presence of B-1 cells in humans

    Time frame: determined over the years study in effect

    an equivalent cell type was isolated in humans

Sponsors and collaborators

Lead sponsor

Northwell Health

Other

Registry information

Important dates

Study start
2009
Primary completion
2014
Study completion
2014
First posted
Jun 23, 2009
Registry last updated
Aug 26, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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