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NCT Number: NCT06704464

Investigation of Validity and Reliability of the Minnesota Manual Dexterity Test in Patients With Multiple Sclerosis

Many assessment tools have been developed and used to evaluate upper extremity functions in multiple sclerosis (MS) patients. While each test has its strengths and weaknesses, the most significant limitation of these tests is that only a limited number assess both hands simultaneously. On the other hand, most daily life activities require the coordinated use of both hands. In MS patients, bilateral impairments in hand functions can also be observed. Therefore, there is a need for bilateral assessment tools.

Unlike many other assessment tools, the Minnesota Manual Dexterity Test (MMDT) allows for simultaneous evaluation of both hands. In addition to manual dexterity, it also assesses hand-eye coordination and gross motor skills. The MMDT consists of five subtests: placing, turning, displacing, single-hand turning and placing, and two-hand turning and placing. The validity of the MMDT has also been examined in MS patients.

Our study aims to evaluate the reliability and validity of the MMDT in MS patients. The cutoff times that best distinguish individuals with MS from healthy individuals will also be examined. The study aims to systematically and thoroughly evaluate the MMDT, establish it as a valid and reliable method for MS patients, and provide a new perspective on assessing hand functions.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sivas Cumhuriyet Üniversity

Sivas, Turkey (Türkiye)

About this study

At baseline, the MMDT, EDSS, 9-hole peg test (9-HPT), ABILHAND survey, and Jebsen-Taylor Hand Function Test (JTHFT) will be applied to the MS group. The MMDT will be repeated seven days after the first application in MS. Healthy controls are going to perform only the MMDT.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age at least 18 years,
  • Neurologist-diagnosed Multiple Sclerosis,
  • Expanded Disability Status Scale (EDSS) score between 0-6.5
  • No MS exacerbation within the last 3 months,
  • Use of stable medication in the last 3 months.

Exclusion criteria

  • Having any vision, hearing or perception problems that may affect the research results,
  • Having an orthopedic problem that may affect manual skills in the upper extremity,
  • Having a cardiovascular, pulmonary disorder

Treatment and study plan

Manual Dexterity

Other

Individuals who meet the inclusion criteria will be evaluated for manual dexterity using MMDT, 9-HPT, ABILHAND, and JTHFT.

Manual Dexterity (only MMDT)

Other

Individuals who meet the inclusion criteria will be evaluated for manual dexterity using MMDT on a predetermined day.

disability level

Other

Individuals who meet the inclusion criteria will be evaluated for disability level using EDSS

Primary outcomes

  1. Minnesota Manual Dexterity Test

    Time frame: baseline (on the predetermined assessment day)

    The Minnesota Manual Dexterity Test (MMDT) is a performance test designed to evaluate hand functions and hand-eye coordination both unilaterally and bilaterally, higher scores mean a worse outcome.

  2. Minnesota Manual Dexterity Test-second

    Time frame: the second assessment will be conducted after the seven days

    The Minnesota Manual Dexterity Test (MMDT) is a performance test designed to evaluate hand functions and hand-eye coordination both unilaterally and bilaterally, higher scores mean a worse outcome.

Secondary outcomes

  1. 9-Hole Peg Test

    Time frame: baseline (on the predetermined assessment day)

    The 9-Hole Peg Test (9-HPT) evaluates hand dexterity based on performance, higher scores mean a worse outcome.

  2. ABILHAND

    Time frame: baseline (on the predetermined assessment day)

    to assess for performance of activity. score range 0-46 point, higher scores mean a better outcome.

  3. The Jebsen Hand Function Test

    Time frame: baseline (on the predetermined assessment day)

    The Jebsen Hand Function Test (JHFT) is one of the objective and standardized tests that assesses fine motor skills and functional hand use by simulating daily living activities, higher scores mean a worse outcome.

  4. The Expanded Disability Status Scale

    Time frame: baseline (on the predetermined assessment day)

    The Expanded Disability Status Scale (EDSS) is a scale used to determine the degree of disability resulting from multiple sclerosis (MS). It evaluates eight functional domains: pyramidal, cerebellar, brainstem, sensory, bowel/bladder, visual, mental, and other functions.Score range 0-10, higher scores mean a worse outcome.

Sponsors and collaborators

Lead sponsor

Gazi University

Other

Collaborators

  • Cumhuriyet University

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Nov 26, 2024
Registry last updated
Mar 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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