Ubamatamab
DrugAdministered per the protocol
Other names: REGN4018
NCT Number: NCT06787612
This study is researching an experimental drug called ubamatamab, also referred to as "study drug". The study is focused on patients who have advanced ovarian cancer.
The aim of the study is to see how safe, tolerable, and effective the study drug is on its own and in combination with other anti-cancer drugs (bevacizumab, cemiplimab, fianlimab and a standard chemotherapy drug, pegylated liposomal doxorubicin [PLD]), referred to as "combination drugs'.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drug and its experimental combinations * How much study drug and fianlimab is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects) and its combinations
Interested in participating?
Request Info18 year and older
Female
Interventional
Phase 2
CancerCare Manitoba, Winnipeg, Manitoba, Canada
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Key Inclusion Criteria:
Key Exclusion Criteria:
NOTE: Other protocol-defined inclusion/exclusion criteria apply
Administered per the protocol
Other names: REGN4018
Administered per the protocol
Other names: Avastin®
Administered per the protocol
Other names: Libtayo®, REGN2810
Administered per the protocol
Other names: REGN3767
Administered per the protocol
Other names: Doxil®, Pegylated liposomal doxorubicin
Administered per the protocol
Other names: Kevzara®, REGN88, SAR153191
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Time frame: Up to 3 years
Contact information is provided by the study sponsor or research team.
Regeneron Pharmaceuticals
Industry
Multi-Arm Phase 2 Platform Study of Ubamatamab (REGN4018; MUC16×CD3 Bispecific Antibody) With or Without Additional Agents in Platinum-Resistant Ovarian Cancer
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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