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NCT Number: NCT07611526

Investigation of the Individual Fatigue Response During Blood Flow Restriction Training

The aim of the present pilot study is to investigate the feasibility of an exercise pressure response approach for assessing physiological strain during BFR training in a clinically supervised setting. Patients undergoing rehabilitation following total knee arthroplasty (TKA) will be included. The results are intended to contribute to an improved evaluation of load management during BFR training.

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Key information

Conditions

Total Knee Anthroplasty

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Bonn

Bonn, North Rhine-Westphalia, 53127, Germany

Location status: Recruiting

Location contact

Alexander Franz, Dr. med., B.Sc.

CONTACT

[email protected]

+491703750718

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elective TKA caused by osteoarthritis of the knee
  • Ability to perform cycling exercise
  • Participant of the Rehab center

Exclusion criteria

  • Open Wounds
  • Iatrogenic Vessel Changes (e.g. Bypasses, Stenting)
  • Sickle Cell Anemia

Treatment and study plan

Cycling BFR

Device

Cycling ergometer with blood flow restriction

Primary outcomes

  1. Exercise Pressure Response

    Time frame: Baseline, continuous analysis throughout the entire training session until immediately after it ends (post-workout)

    Arterial Pulsation Pressure (mmHg) Assessed Continuously During Blood Flow Restriction Training

Secondary outcomes

  1. Muscle Strength [1RM]

    Time frame: Baseline- vs. immediately after the exercise (Pre-Post-Comparison)

    Quadriceps Isometric Maximal Strength Assessed by Instrumented Leg Press Dynamometry

Study contacts

Contact information is provided by the study sponsor or research team.

Alexander Franz, Dr. med., B.Sc.

CONTACT

[email protected]

+491703750718

Sponsors and collaborators

Lead sponsor

University Hospital, Bonn

Other

Registry information

Official study title

Investigation of the Individual Fatigue Response During Blood Flow Restriction Training on a Cycle Ergometer Following Orthopedic Surgical Interventions

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
May 28, 2026
Registry last updated
Jul 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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