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Completed

NCT Number: NCT04853654

Investigation of the Effects of Selective Exercise Training in Multiple Sclerosis

Selective exercise programs specific to muscle groups, with the workload to be done in line with the muscle's own structure, can enable more strength to be released with less fatigue in MS, and this increase in strength can increase balance and functional activities. to determine the effects of type training (selective exercise training), eccentric and concentric training on function, balance, fatigue and muscle architecture.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Behavior Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Exercise Immune System Diseases Motor Activity Nervous System Diseases

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zekiye İpek Katırcı Kırmacı

Gaziantep, Turkey (Türkiye)

About this study

Recovery and enhancement of muscle function in MS is one of the main goals in physiotherapy and rehabilitation. In literature studies, it is stated that eccentric and concentric exercises are effective exercise approaches in increasing strength and reducing fatigue. However, the best exercise method is not yet clear in terms of providing better performance adaptation with less fatigue. Considering the architectural features of the lower extremity muscles, it is aimed to increase the angle of pennation with programs that include concentric strengthening of the quadriceps, gastro-soleus and gastrocnemius muscles, which are suitable muscle groups to produce large forces by design. With programs that include eccentric strengthening of the hamstring and tibialis anterior muscles that function in a wide range of motion and have high excursion ability, it is aimed to increase fiber length.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between the ages of 18-50,
  • With an Extended Disability Status Scale (EDSS) score of 4 or less,
  • No regular exercise habit
  • Able to walk on the treadmill,
  • No pregnancy,
  • Not receiving corticosteroid treatment in the last month,
  • Fampridine etc. in the last 1 month. not taking medication,
  • Patients who have not received Botox treatment in the last 6 months

Exclusion criteria

patients who do not agree to volunteer

Treatment and study plan

Exercise

Other

exercise training for 8 weeks

Primary outcomes

  1. muscle architecture parameter 1

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    The pennation angle were evaluated with Ultrasound

  2. muscle architecture parameter 2

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    The fiber length were evaluated with Ultrasound

  3. muscle architecture parameter 3

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    The muscle thickness were evaluated with Ultrasound

  4. Muscle strength

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    low extremity muscles were evaluated with hand dynamometer

Secondary outcomes

  1. walking fatigue

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    Walking Fatigue Index

  2. perceived fatigue

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    Fatigue Severity Scale

  3. physical fatigue

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    Modified Borg Scale before and after 6-minute walking test

  4. static balance

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    Single standing tests

  5. dynamic balance

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    4 square step tests

  6. Functional activities 1

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    timed-up go test

  7. Functional activities 2

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    2-minute walk test

  8. Functional activities 3

    Time frame: Change from Baseline at 8th weeks and 12th weeks

    25-feet walk test

Sponsors and collaborators

Lead sponsor

Sanko University

Other

Registry information

Official study title

Investigation of the Effects of Selective Exercise Training on Muscle Architecture, Balance, Function and Fatigue in Multiple Sclerosis

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Apr 21, 2021
Registry last updated
Jan 13, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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