Investigation of the Effects of Physiotherapy in Patients With Platelet Rich Plasma (PRP) Applied Knee Osteoarthritis

This study evaluates effects of PRP and physiotherapy on pain, physical function and quality of life in patients with knee osteoarthritis.

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Key information

Conditions

Knee Osteoarthritis Arthritis Behavior Joint Diseases Motor Activity Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

45 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Hacettepe University

Ankara, Samanpazari, 06100, Turkey (Türkiye)

About this study

PRP has been reported to have a low to moderate level of evidence in patients with knee osteoarthritis (OA) in reducing pain and improving function. Similarly, in individuals with knee osteoarthritis, exercise has been reported to be effective in reducing the pain and improving physical function of the knee OA patient in the short term, and may be even more effective with individual exercise programs. However, there is no study examining the effect of PRP and exercise together. PRP and exercise can be more effective together. The aim of our study was to investigate the effects of physiotherapy on pain, physical function and quality of life in patients with knee OA who underwent PRP injection.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Grade 2-3 according to Kellgren Lawrence osteoarthritis classification,
Patients with knee osteoarthritis who underwent PRP injection at least three days ago,
Being volunteer

Exclusion criteria

Any intra-articular application and / or physiotherapy and rehabilitation in the last 6 months,
Have any other orthopedic problems involving the lower extremities
Having cognitive problems,
Having additional neurological, rheumatologic and / or oncological problems

Treatment and study plan

Exercise

Other

Exercise specific to knee osteoarthritis.

Primary outcomes

Change from Baseline Pain Level at Six Week

Time frame: At baseline, six week

Pain change will be measured throughout Study and Follow-up with Visual Analog Scale. This scale is a 100 millimeter line drawn horizontally on an A4 sheet of paper. The left end of the line shows "no pain at all", the right end shows "my pain is as bad as it could be", while the remaining part shows the intermediate values. So minimum score was 0, and maximum score was 100. The patient is asked to mark the severity of the pain on the chart. Validity and reliability were made. The minimal clinical significance difference in chronic low back pain was 20 millimeters.

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Investigation of the Effects of Physiotherapy on Pain, Physical Function and Quality of Life in Patients With PRP Applied Knee Osteoarthritis

Important dates

Study start: 2019
Primary completion: 2020
Study completion: 2020
First posted: May 13, 2020
Registry last updated: Feb 16, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed