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NCT Number: NCT07448467

Investigation of the Effectiveness of Progressive Resistance Exercise Training in the Management of Lymphedema.

This study aims to investigate the effect of progressive resistance exercise training on the clinical findings and functional outcomes of lymphedema in individuals who develop upper extremity lymphedema after breast cancer treatment (surgery, chemotherapy and/or radiotherapy).

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Key information

Conditions

Lymphedema Breast Cancer Breast Diseases Breast Neoplasms Hemic and Lymphatic Diseases Lymphatic Diseases Neoplasms Neoplasms by Site Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Re-Heal Physiotherapist Sude BOYVADAOĞLU Healthy Living Center

Adana, Turkey (Türkiye)

Location status: Recruiting

Location contact

Sevinj RAFILI

CONTACT

+905411127284

About this study

The study is designed as a randomized controlled trial. Volunteers participating in the study will consist of individuals who have developed lymphedema after breast cancer and who agree to participate in the study. Volunteer female participants will be divided into 2 groups of equal numbers. Participants in the control group will receive lymphedema treatment, while participants in the exercise group will perform progressive resistance upper extremity exercises at home, 2 days a week for 12 weeks. All exercises will be performed with compression bandages. All participants will be evaluated before and after treatment using a hand dynamometer, the Disabilities of the Arm, Shoulder and Hand Scale, and the Lymphedema Quality of Life Questionnaire-Arm.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being between 18 and 60 years of age.
  • Being included in the study 3 months after undergoing surgery.
  • Being able to tolerate compression bandages or compression garments.

Exclusion criteria

  • Individuals who need to restart active cancer treatment during the study period. - Being within the first 3 months after surgery.

Treatment and study plan

Control

Other

Classic lymphedema physiotherapy will be applied.

Exercise

Other

In addition to classic lymphedema physiotherapy, a progressive resistance exercise training program will be implemented.

Primary outcomes

  1. LYMphedema Quality of Life

    Time frame: 14 weeks

    The Lymphedema Quality of Life Questionnaire, a validated disease-specific QoL tool, was also administered at baseline and at day 28. Overall QoL is scored on a single item by the patient on a scale of 1-10.

  2. Disabilities of the Arm, Shoulder and Hand

    Time frame: 14 weeks

    Validated outcome measure that asks an individual to self-report about the ability to perform certain upper limb activities. Questions are responded on a 5-point Likert scale.

Study contacts

Contact information is provided by the study sponsor or research team.

Ömer ŞEVGİN

CONTACT

[email protected]

+905069787535

Sponsors and collaborators

Lead sponsor

Uskudar University

Other

Registry information

Official study title

Investigating the Effectiveness of Progressive Resistance Exercise Training in the Management of Lymphedema Developing After Breast Cancer Treatment: a Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 4, 2026
Registry last updated
Mar 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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