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NCT Number: NCT06965634

Investigation of the Effectiveness of Lung Ultrasonography in Intraoperative Fluid Management

Adequate and balanced fluid resuscitation is one of the cornerstones of intraoperative patient management. Over-resuscitation leading to positive fluid balance is associated with increased postoperative mortality and morbidity.

Invasive and non-invasive technologies can be used for the adequacy of intraoperative fluid therapy.

Lung ultrasonography (LUS) is a safe and accurate bedside imaging method. LUS, which is frequently used in the diagnosis of postoperative hypoxemia, has also begun to be preferred for fluid management in intensive care units.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

About this study

In this study, we aimed to investigate the effectiveness of intraoperative LUS data in the control of fluid therapy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with surgery with laparotomy

Exclusion criteria

  • Chronic obstructive pulmonary disease
  • Passed lung operation
  • Uncontrolled hypertension
  • Acute or chronic kidney failure

Treatment and study plan

Lung ultrasound

Device

Lung ultrasonography ; lung ultrasonography will be applied in 4 quadrants according to the LUS protocol and LUS score will be created.

Other names: Lung ultrasound score

Primary outcomes

  1. LUS

    Time frame: peroperative

    Lung ultrasound score (LUS) Lung ultrasonography; Lung ultrasound score will be created by performing ultrasonography in 4 quadrants according to the previously defined protocol.

    0 points indicated the presence of only A lines, less than 2 B lines

    • point indicated 1-2 B lines
    • points indicated the presence of more than 3 well-spaced B lines;
    • points indicated the presence of combined B lines

Secondary outcomes

  1. PVI

    Time frame: peroperative

    Pulse variable index (PVI) will be measured by finger pulse oximetry with the MASİMO device.

  2. CVP

    Time frame: peroperative

    Central venous pressure(CVP)

    Pressure values measured by a central venous catheter applied by jugular or subclavian route

  3. postoperative pulmonary complication

    Time frame: postoperative 6th hour

    hypoxia (partial oxygen pressure below 95 on pulse oximetry and 10% decrease from the initial value) atelectasis

  4. biochemical data 1

    Time frame: postoperative 6th hour

    glomerular filtration rate (GFR) values normal results range from 90 to 120 mL/min/1.73 m2.

  5. biochemical data 2

    Time frame: postoperative 6th hour

    Blood urea nitrogen value mg/dl

  6. biochemical data 3

    Time frame: postoperative 6th hour

    Blood creatinine value mmol/dl

  7. Mechanical ventilation data 1

    Time frame: peroperative

    End-Tidal Carbon Dioxide Pressure mm/hg The partial pressure of CO2 detected at the end of exhalation is between 35 and 45 mm Hg or 4.0 to 5.7 kPa.

  8. Mechanical ventilation data 2

    Time frame: peroperative

    Peak inspiratory pressure Values Peak inspiratory pressure is the highest pressure applied to the lungs during inhalation and should be kept below 35 cmH2O.It is automatically measured by respirators.

  9. Mechanical ventilation data 3

    Time frame: peroperative

    Tidal Volume value Tidal volume is the volume of gas moving into and out of the lungs with each breath. Normal tidal volume is 6 to 8 mL/kg, regardless of age. It is automatically measured by respirators.

Study contacts

Contact information is provided by the study sponsor or research team.

Korgün Ökmen, PhD.

CONTACT

[email protected]

05057081021

Sponsors and collaborators

Lead sponsor

Korgün Ökmen

Other Gov

Registry information

Official study title

Investigation of the Effectiveness of Lung Ultrasonography in the Management of Intraoperative Fluid Therapy, Prospective Observational Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 11, 2025
Registry last updated
May 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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