Investigation of the Effectiveness of Craniosacral Therapy in Patients With Multiple Sclerosis.

Dynamic posturography is a device that converts the balance of the individual under changing floor, environment and stimulus conditions into computerized data with receivers on the floor.

Heart rate variability is a tool that allows the investigation of cardiovascular autonomic function through the measurement of variations in RR intervals and provides valuable information about the control of autonomic nervous system.

A total of 32 MS patients, 16 in both groups, will be included in the study.

Visual analog scale will be used to examine pain levels of participants. Individuals are presented with a line numbered evenly from 1 to 10 and asked to mark the point corresponding to their pain intensity. A higher score indicates that severity of pain increasing.

The Central Sensitization Scale (CSS) will be used. The CSS was developed as a screening tool to better assess symptoms thought to be associated with CS, categorize syndromes, define disease severity, measure sensitivity, and assist physicians and clinicians in treatment planning by minimizing or, if possible, avoiding unnecessary diagnostic and treatment procedures. Part A of the SSI includes all CS symptoms and is the part that will help clinicians to recognize the CS patient. According to the scale, those with a score above 40 are considered to have developed CS.

Fatigue Severity Scale will be applied. Each item in the self-administered 9-question scale, which reflects the situation of the individuals in the last week, consists of "1" Strongly disagree, "7" It consists of a score between "1-7" corresponding to the statement "I agree". As a result of dividing the total score obtained by the number of questions, ">6.1" corresponds to chronic fatigue syndrome and "<2.8" to no fatigue. The lower the total score, the less fatigue is interpreted

Pittsburgh Sleep Quality Index (PSQI) will be used. The PSQI is a self-report scale that assesses sleep quality and sleep disturbance over a one-month period. The PDQI has 7 components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, sleep medication use and daytime dysfunction. Some of the components are indicated by a single item, while others are obtained by grouping several items. Each item is evaluated on a 0-3 point scale and the sum of the 7 component scores constitutes the total PDQI score. The total score has a value between 0-21, with a high total score indicating poor sleep quality.

Multiple Sclerosis Quality of Life Scale (MSQoL-54) scale will be used. It was created by Vickrey et al. (1995) by adding 18 items specific to MS to the SF-36 quality of life scale used in many diseases. The MSQoL was created by adding 18 items to the items in the SF-36 related to general health perception (5 items), energy/fatigue (4 items), social function (2 items), emotional flexibility (5 items), limitations due to emotional problems (3 items), limitations due to physical problems (4 items), physical function (10 items), pain (2 items) and change in health. The 2 main groups of the scale score between 0-100, with higher scores indicating higher quality of life.