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NCT Number: NCT06188806

Investigation of the Effect of Proximal and Distal Adductor Canal Block in Knee Replacement Surgery

to investigate the effect of adductor canal block applied with two different approaches in the treatment of pain after TKA surgery on pain control and functional mobility.

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Key information

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Umraniye Education and Research Hospital

Istanbul, Umraniye, 34734, Turkey (Türkiye)

Location status: Recruiting

Location contact

ZELİHA TUNCEL, ass prof

CONTACT

[email protected]

5053577483

About this study

This prospective randomized trial is randomly divided into 3 groups using the method. Total knee arthroplasty is performed by the same surgical team.

is applied. The patients were divided into proximal ACB applied, distal ACB applied and control groups.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Medications for unilateral TKA surgery
  • Patients aged 18-85
  • ASA 1-3

Exclusion criteria

  • Patients under 18 years of age and over 85 years of age
  • Patients with ASA 4 and above
  • Patients with cognitive impairment
  • Patients with application site infection
  • Patients allergic to local anesthesia
  • Patients receiving anticoagulant therapy
  • Patients with bleeding diathesis
  • Patients with chronic opioid or substance use
  • Patients with insulin-dependent diabetes mellitus
  • patients with neuropathy
  • patients with hepatic or renal failure
  • Patients who do not accept the procedure to be applied

Treatment and study plan

ADDUKTOR CANAL BLOCK

Other

All patients who will undergo adductor canal block are sedated with midazolam 0.03 mg/kg in the preoperative preparation room, after standard monitoring. After 2-3 ml skin infiltration with 2% lidocaine under sterile conditions, a block is applied under USG guidance.To verify block success, sensory function is assessed by pinprick testing along the saphenous nerve distribution by comparing the pinprick sensation to the unaffected limb.All patients are monitored in the operating room and in a sitting position, 10-20 mg (2-4 ml) of heavy marcaine (0.5% bupivacaine hydrochloride and dextrose monohydrate) is applied to the subarachnoid space by entering the L3-4 or L4-5 space with a 25-gauge Whitrace needle.For postoperative multimodal analgesia, which is routinely applied to all patients, intravenous PCA (patient controlled analgesia )tramadol and paracetamol 10 mg / kg iv (8 hours apart) will be given.

Control Group

Other

No nerve block procedure is applied to patients.All patients are monitored in the operating room and in a sitting position, 10-20 mg (2-4 ml) of heavy marcaine (0.5% bupivacaine hydrochloride and dextrose monohydrate) is applied to the subarachnoid space by entering the L3-4 or L4-5 space with a 25-gauge Whitrace needle.For postoperative multimodal analgesia, which is routinely applied to all patients, intravenous PCA (patient controlled analgesia) tramadol 50 mg at 10 mg / hour basal rate after loading (20 mg bolus dose + 30 minutes lock time) and paracetamol 10 mg / kg iv (8 hours apart) will be given.

Primary outcomes

  1. VISUAL ANALOGUE SCALE(VAS)

    Time frame: POSTOPERATIVE 6, 12 AND 24 HOURS

    VAS pain score was evaluated as "no pain" (score=0) and "worst pain" (score=10) and was divided into 3 groups according to the World Health Organization's pain intensity scale: score <3 mild pain, 3-6 mild-moderate. degree pain and >6 moderate-severe pain.

Secondary outcomes

  1. first mobilization time

    Time frame: within postoperative 24 hours

    The first postoperative mobilization hours of the patients will be recorded.

  2. length of hospital stay

    Time frame: ONE WEEK

    The time between patients' admission and discharge will be recorded.

  3. opioid use

    Time frame: within postoperative 24 hours

    Intravenous PCA will be applied to each patient and the total tramadol dose spent will be calculated.intravenous PCA (patient controlled analgesia) tramadol 50 mg at 10 mg / hour basal rate after loading (20 mg bolus dose + 30 minutes lock time)

Study contacts

Contact information is provided by the study sponsor or research team.

Zeliha TUNCEL

CONTACT

[email protected]

+90 505 357 74 83

Sponsors and collaborators

Lead sponsor

Umraniye Education and Research Hospital

Other Gov

Registry information

Official study title

Investigation of the Effect of Proximal and Distal Adductor Canal Block on Pain Control and Functional Mobility in Total Knee Prosthesis Surgery Performed Under Spinal Anesthesia

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Jan 3, 2024
Registry last updated
Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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