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NCT Number: NCT07142018

Investigation of the Effect of Hyperbaric Oxygen Therapy in Patients With Avascular Necrosis

Avascular necrosis is a condition that occurs when bone tissue loses sufficient blood flow. This condition causes bone cells to die and, as a result, bone structure to deteriorate.

Hyperbaric oxygen therapy is a treatment method used in patients with avascular necrosis.

Avascular necrosis can significantly affect the quality of life of patients. The aim of this study was to investigate the effects of hyperbaric oxygen therapy on physical capacity, depressive symptoms, and quality of life in patients diagnosed with avascular necrosis.

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This study is active but is not currently recruiting participants.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Kartal Dr Lutfi Kirdar City Hospital

Istanbul, Turkey (Türkiye)

About this study

Avascular necrosis is a condition that occurs when bone tissue loses sufficient blood flow. This condition causes bone cells to die and, as a result, bone structure to deteriorate. It is commonly seen in joints such as the hip, knee, ankle, and shoulder.

Hyperbaric oxygen therapy is a treatment method used in patients with avascular necrosis. In hyperbaric oxygen therapy, patients breathe 100% oxygen under high pressure. This treatment can help treat avascular necrosis by increasing oxygen, promoting new blood vessel formation, reducing inflammation, and facilitating cell repair mechanisms.

Avascular necrosis can significantly affect the quality of life of patients. The effects of avascular necrosis on quality of life can be summarized as follows: Avascular necrosis often causes severe pain and limited mobility in the joint areas. These physical symptoms can prevent patients from performing their daily activities, leading to social isolation and a decline in overall quality of life.

The aim of this study was to investigate the effects of hyperbaric oxygen therapy on physical capacity, depressive symptoms, and quality of life in patients diagnosed with avascular necrosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be over 18 years of age,
  • Receive hyperbaric treatment,
  • Be diagnosed with avascular necrosis,
  • Have stage 1-2 avascular necrosis according to the Ficat classification,
  • Be able to understand and speak Turkish,
  • Be able to read and write,

Exclusion criteria

  • Having undergone orthopedic surgery on the lower extremities,
  • Having cardio-respiratory failure that prevents walking,
  • Having a disorder related to the musculoskeletal system other than AVN
  • Having a diagnosis of avascular necrosis classified as stage 3-4 according to the Ficat classification
  • Presence of varicose veins,
  • Presence of urinary stress incontinence,
  • Presence of systemic or rheumatological disease,
  • Pregnancy,
  • Refusal to participate in the study.

Treatment and study plan

Primary outcomes

  1. tinetti performance oriented mobility assessment measure

    Time frame: 1 week

    The Tinetti assessment tool is an easily administered task-oriented test that measures an older adult's gait and balance abilities. Scoring: A three-point ordinal scale, ranging from 0-2. "0" indicates the highest level of impairment and "2" the individuals independence.

  2. Beck Depression Inventory

    Time frame: 1 week

    It is a 21-item, self-report rating inventory that measures characteristic attitudes and symptoms of depression.

  3. Short form 36

    Time frame: 1 week

    SF-36 is a set of generic, coherent, and easily administered quality-of-life measures. These measures rely upon patient self-reporting and have been widely used.

Sponsors and collaborators

Lead sponsor

Dr. Lutfi Kirdar Kartal Training and Research Hospital

Other Gov

Registry information

Official study title

Investigation of the Effect of Hyperbaric Oxygen Therapy on Physical Capacity, Depressive Symptoms, and Quality of Life in Patients With Avascular Necrosis

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 26, 2025
Registry last updated
Aug 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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