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Completed

NCT Number: NCT07267923

Investigation of the Acute Effects of Traditional and Functional IMT on Muscle Oxygenation in COPD

This study aims to compare the effects of functional and conventional inspiratory muscle training (IMT) on post-exercise muscle deoxygenation in individuals with Chronic Obstructive Pulmonary Disease (COPD). Participants will complete both training modalities on separate days. A 2-minute walk test (2MWT) will be performed baseline, and after each session. Muscle oxygenation (SmO₂) will be assessed using near-infrared spectroscopy . Dyspnea and fatigue will be evaluated with the Modified Borg Scale, and heart rate and oxygen saturation (SpO₂) will be measured by pulse oximetry. Measurements will be recorded before, after training and at the end of the walking test.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease (COPD) Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gulhane Faculty of Physiotherapy and Rehabilitation

Ankara, Keçiören, 06018, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being 18 years of age or older,
  • Having a diagnosis of COPD,
  • Being in stage II-III according to the GOLD classification,
  • Being able to mobilize independently.

Exclusion criteria

  • Having a recent exacerbation or complication requiring hospitalization,
  • Having had a respiratory tract infection within the past month,
  • Having any disease or medical condition that prevents participation in exercise, -Having cognitive impairment (a score of <24 on the Mini-Mental Test).

Treatment and study plan

Traditional inspiratory muscle training

Other

Traditional inspiratory muscle training is a form of training performed using a resistive breathing device that provides resistance to the muscles involved in inspiration. Inspiratory muscle training will be performed using a portable pressure-threshold device (POWERbreathe Classic IMT - Light Resistance). IMT will be administered in a seated position with upper extremities supported and the upper chest/shoulders relaxed. The training procedure will be explained to each participant and performed for 15 minutes at 40% of the maximal inspiratory pressure (MIP).

Functional Inspiratory Muscle Training (IMT)

Other

Functional inspiratory muscle training (IMT) is defined as inspiratory muscle training performed while maintaining core stabilization and postural control. Functional IMT consists of a warm-up period, core exercises, dynamic trunk activation combined with upper extremity movements, postural control exercises, and a cool-down period. The participant performs these exercises simultaneously with inspiratory muscle training.

Primary outcomes

  1. Muscle oxygenation levels (SmO₂)

    Time frame: 1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

    Muscle oxygenation (SmO₂) will be assessed using near-infrared spectroscopy .

Secondary outcomes

  1. Fatigue

    Time frame: 1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

    Fatigue will be assessed before and after the walking test using the Borg scale. The scale is scored from 0 to 10, with 0 being no fatigue and 10 being extreme fatigue.

  2. Dyspnea

    Time frame: 1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

    Dyspnea severity will be assessed using the Modified Borg Scale. It consists of ten items that describe the severity of dyspnea according to degree. The scale is scored from 0 (no shortness of breath) to 10 (very severe).

  3. Heart rate

    Time frame: 1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

    Heart rate value will be measured with a pulse oximeter.

  4. Saturation (SPO2)

    Time frame: 1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

    Saturation values will be measured with a pulse oximeter.

  5. hemoglobin

    Time frame: 1. day - baseline measurement-before and after 2MWT , 1. day- before and after IMT and after 2MWT 2. day- before and after FIMT and after 2MWT

    The hemoglobin value of muscle tissue will be measured using the near infrared spectroscopy (NIRS) method.

Sponsors and collaborators

Lead sponsor

Saglik Bilimleri Universitesi

Other

Registry information

Official study title

Investigation of the Acute Effects of Traditional and Functional Inspiratory Muscle Training on Muscle Oxygenation in Chronic Obstructive Pulmonary Disease

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 5, 2025
Registry last updated
Apr 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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