Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

This study investigates the psychophysiological correlations of aggression and response to aversive stimuli in a population of 133 children clinically diagnosed with conduct disorder (CD) and/or attention-deficit/hyperactivity disorder (ADHD). Data was gathered about participants' level of aggression through the Reactive-Proactive Aggression Questionnaire (RPQ). The stimuli that were presented to the participants included 1) a loud sound, 2) threatening photographs from the International Affective Picture System (IAPS), and 3) the Trier Social Stress Task (TSST). Participants' psychophysiological features of heart rate and galvanic skin conductance were measured and analyzed in relation to their RPQ scores and clinical diagnosis.

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Key information

Conditions

Conduct Disorder ADHD Attention Deficit Disorder with Hyperactivity Attention Deficit and Disruptive Behavior Disorders Mental Disorders Neurodevelopmental Disorders Oppositional Defiant Disorder

Age range

7 year–16 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects between ages 7 and 16 years
Subjects who fulfil all criteria for a DSM-IV diagnosis of ADHD, conduct disorder, or oppositional defiant disorder
Subjects with willingness to participate in a randomized, double-blind controlled trial
Subjects with complete written, informed parental consent and child assent
Subjects with IQ of 70 or more

Exclusion criteria

Subjects who have IQ in the below 70
Subjects who are younger than 7 years old or older than 16 years old
Those without written parental consent
Those with brain pathology such as serious head injury, epilepsy, etc.

Treatment and study plan

No intervention was administered for the purpose of this study.

Other

No intervention was administered for the purpose of this study. Observations were carried out for all participants.

Primary outcomes

Heart Rate

Time frame: 7 minutes

For Trier Social Stress Task
Skin Conductance Response

Time frame: 4 minutes

For loud sound
Skin Conductance Response

Time frame: 4 minutes

For threatening photograph

Sponsors and collaborators

Lead sponsor

Yale-NUS College

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2015
Study completion: 2015
First posted: Oct 31, 2018
Registry last updated: Oct 31, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed