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NCT Number: NCT07538414

Investigation of Patients Presenting With Acute Functional Neurological Symptoms

Retrospective Single-center Analysis of Patients Presenting With Acute Neurological Symptoms, Aiming to Characterize the Frequency, Clinical Features, Diagnostic Pathways, and Healthcare Utilization of Patients with Functional Neurological Diseases

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Key information

Conditions

Functional Neurological Disorder Conversion Disorder Mental Disorders Somatoform Disorders

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients older than 16 years old presenting as an emergency case to the University Hospital Basel between 1 January 2012 and 31 March 2026
  • with acute neurological symptoms requiring immediate neurological work-up (e.g, acute motor or sensory disturbance, acute speech disorder, acute vestibular disorder, acute cognitive disorder, acute consciousness disorder, acute seizure disorder)
  • and a documented diagnostic evaluation during hospitalization.

Exclusion criteria

  • Documented refusal for further use of health related data for research purposes
  • Insufficient documentation to determine diagnosis or clinical course
  • Incomplete or inconsistent datasets compromising valid endpoint determination
  • Younger than 16 years

Treatment and study plan

collection of patient data

Other

collection of patient data

Primary outcomes

  1. Frequency of FND

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

    The primary endpoint is the proportion of patients presenting with acute neurological symptoms who receive a diagnosis or likely differential diagnosis of Functional Neurological Disorder (FND) during their index hospital admission.

Secondary outcomes

  1. Secondary Outcomes

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

    Diagnostic Process Measures (%): Referral patterns and evaluation of alternative or concurrent neurological diagnoses.

  2. Secondary Outcomes

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

    Diagnostic Resource Utilization (%): Clinical examination findings, neuroimaging, neurophysiological testing, and laboratory investigations.

  3. Secondary Outcomes

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

    Healthcare Utilization and Outcomes (%): Discharge destination, readmission, outpatient follow-up, and in-hospital mortality.

  4. Secondary Outcomes

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

    Quality of Care Associations (%) Demographic and clinical variables associated with diagnostic performance and healthcare utilization.

  5. Secondary Outcomes

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

    Comparative Analyses: FND vs Non-FND (%): Differences in diagnostics, resource utilization, escalation of care, and short-term outcomes.

  6. Secondary Outcomes

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

    Subtype Analyses (%): Differences across FND subtypes in presentation, diagnostics, management, and outcomes.

  7. Secondary Outcomes

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

    Time to Definitive Diagnosis (days)

  8. Secondary Outcomes

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

    Length of Hospital Stay (days)

Study contacts

Contact information is provided by the study sponsor or research team.

Urs Fisch, MD PhD

CONTACT

[email protected]

+41 61 265 2525

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

Functional Neurological Disorders in Acute Hospital Care

Acronym: FONDA

Important dates

Study start
2026
Primary completion
2050
Study completion
2050
First posted
Apr 20, 2026
Registry last updated
Apr 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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