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Completed

NCT Number: NCT07029074

Investigation of Inspiratory Muscle Training Applied at Different Intensities on Intercostal Muscle Oxygenation

In this study, it was aimed to investigate the acute effect of inspiratory muscle training of different intensities on intercostal muscle oxygenation in healthy individuals.

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Key information

Conditions

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kırşehir Ahi Evran University, Physical Therapy and Rehabilitation Center, Cardiopulmonary Unit

Kırşehir, Turkey (Türkiye)

About this study

The functional activity of the respiratory system must be regular and efficient in order to meet the oxygen needs of tissues and organs. The mechanical function of the respiratory system is significantly related to the working capacity of the respiratory muscles. The diaphragm is the primary muscle that provides respiratory functions among the respiratory muscles.The external intercostal muscles help with the inspiration, while the internal intercostal muscles help with the expiration. The basis of inspiratory muscle training is to reduce dyspnea, increase inspiratory muscle function and exercise tolerance. Inspiratory muscle training provides an increase in muscle strength by increasing inspiratory muscle strength, reducing metaboreflex activity and increasing blood flow to the muscles. Training is thought to minimize the effects of activation of inspiratory muscle metaboreflex in both healthy individuals and patients with heart failure. In chronic respiratory patients, forced inspiration effort reduces capillary perfusion of the respiratory muscles, thus increasing the oxygen demand of the muscle. Muscle oxygen saturation shows the oxygen uptake and oxygen consumption of the muscle. It aims to investigate the mechanisms involved in the metaboreflex response to respiratory fatigue in inspiratory muscle training, which severity will acutely reduce it more.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physically active (doing moderate intensity physical activity for at least 3 days a week for 150 minutes / week)
  • Volunteer to participate in the study

Exclusion criteria

  • Healthy individuals with any diagnosed chronic or systemic disease,
  • Smoke 10 packs x years or more,
  • Pneumonia or any acute infection,
  • Psychiatric disorder will excluded in the study.

Treatment and study plan

Sham inspiratory muscle training (MIP 0%)

Device

POWERbreathe Wellness (POWERbreathe International Ltd.., England, UK) device will be used for inspiratory muscle training.

MIP 30% inspiratory muscle training

Device

POWERbreathe Wellness (POWERbreathe International Ltd.., England, UK) device will be used for inspiratory muscle training.

MIP 70% inspiratory muscle training

Other

POWERbreathe Wellness (POWERbreathe International Ltd.., England, UK) device will be used for inspiratory muscle training.

Primary outcomes

  1. Evaluation of intercostal muscle oxygenation

    Time frame: Second, Third and Fourth day

    Before the inspiratory muscle training sessions, the muscle oxygen saturation (SmO2) of the intercostal muscles in recovery during and after the training session will be measured using a Moxy® monitor (Moxy, Fortiori Design LLC, Minnesota, USA).

  2. Evaluation of intercostal muscle total hemoglobin level

    Time frame: Second, Third and Fourth day

    Before the inspiratory muscle training sessions, total hemoglobin level (THb) of the intercostal muscles in recovery during and after the training session will be measured using a Moxy® monitor (Moxy, Fortiori Design LLC, Minnesota, USA).

Secondary outcomes

  1. Evaluation of respiratory muscle strength

    Time frame: First day

    An electronic mouth pressure device will be used to evaluate respiratory muscle strength. Patients will have maximal inspiratory pressure and maximal expiratory pressure measured with a mouth pressure measuring device.

  2. Evaluation of respiratory muscle endurance

    Time frame: First day

    The incremental threshold loading test will be used to evaluate respiratory muscle endurance. The PowerBreathe Wellness® (HaB International Ltd. Southam, UK) will be used in the incremental threshold loading test.

  3. Evaluation of physical activity level

    Time frame: First day

    The physical activity level of individuals will be evaluated using the short form of the International Physical Activity Questionnaire. A score is obtained by multiplying the metabolic equivalent (MET) value by days and minutes. When calculating the walking score, the walking time will be multiplied by 3.3 METs; when calculating the moderate intensity activity score, it will be multiplied by 4 METs; when calculating the vigorous activity score, it will be multiplied by 8 METs. Physical activity levels will be classified as physically inactive (3000 MET-min/week).

Sponsors and collaborators

Lead sponsor

Kirsehir Ahi Evran Universitesi

Other

Registry information

Official study title

Investigation of the Acute Effect of Inspiratory Muscle Training Applied at Different Intensities on Intercostal Muscle Oxygenation

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 19, 2025
Registry last updated
Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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