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OpenTrials
Completed

NCT Number: NCT01025024

Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

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Key information

Conditions

Single-nucleotide Polymorphism (SNP) for Glaucoma Eye Diseases Glaucoma Glaucoma, Open-Angle Ocular Hypertension

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chungnam National University Hospital

Daejeon, 301-721, South Korea

About this study

Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of primary open angle glaucoma

Exclusion criteria

  • Primary open angle glaucoma combined with congenital ocular disease
  • Primary open angel glaucoma combined with other ocular disease
  • Significant systemic disease other than systemic hypertension and diabetes

Treatment and study plan

SNP analysis of the DNA

Genetic

SNP analysis of the DNA obtained from peripheral blood sample

Primary outcomes

  1. genotyping for the SNP associated with primary open angle glaucoma

    Time frame: one year

Secondary outcomes

  1. genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns

    Time frame: one year

Sponsors and collaborators

Lead sponsor

Chungnam National University

Other

Collaborators

  • Korea Advanced Institute of Science and Technology
  • Korea Healthcare Technology R&D Project

Registry information

Official study title

Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients Patients, A Single-nucleotide Polymorphism(SNP)Analysis for Primary Open Angle Glaucoma

Important dates

Study start
2007
Primary completion
2009
Study completion
2009
First posted
Dec 3, 2009
Registry last updated
Dec 3, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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