Skip to main content
OpenTrials
Completed

NCT Number: NCT03037216

Investigation of Exercise Training-Induced Myokines and Adipolkines in Humans

The purpose of this study is to find out whether exercise training leads to changes in the blood that are produced by exercised muscles and if these changes produce new hormones that affect the body's regulation of sugar and body weight.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy Behavior Motor Activity

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Joslin Diabetes Center

Boston, Massachusetts, 02215, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18-35. Body mass index (BMI) must be ≥18.5 and ≤27 kg/m2. HbA1c values ≤5.7%

Exclusion criteria

  • Age <18 and >50
  • HbA1c ≥ 5.7%; heart or lung disease
  • acute systemic infection accompanied by fever, body aches, or swollen lymph glands
  • BMI > 27 kg/m2
  • current dieting or weight loss efforts
  • current pregnancy or breastfeeding
  • known history of HIV/AIDS; cancer
  • biochemical evidence of renal or hepatic dysfunction; renal or liver disease demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis
  • recent blood donation
  • clinical history of stroke
  • hypertension (systolic > 140 mmHg or diastolic > 90 mmHg)
  • type 1 or 2 diabetes; inability to exercise at 50% of predicted heart rate (HR) reserve at baseline
  • Participants taking beta-blockers Participants who screen positive for The American Heart Association's contraindications to exercise testing

Treatment and study plan

Exercise intervention

Other

10 Week aerobic exercise training

Primary outcomes

  1. Changes in circulating proteins in the blood.

    Time frame: Baseline vs. Post 10 Week Training.

Sponsors and collaborators

Lead sponsor

Joslin Diabetes Center

Other

Collaborators

  • Daiichi Sankyo

Registry information

Important dates

Study start
2016
Primary completion
2019
Study completion
2020
First posted
Jan 31, 2017
Registry last updated
Aug 20, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.