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Completed

NCT Number: NCT00784004

Investigation of Efficiency of Breathing With Different Breathing Patterns

Our aim in this study is to investigate the efficiency of the breathing with different breathing patterns. Ten volunteers and twenty patients having respiratory problems will be coached on their breathing through specific masks which will provide four different breathing patterns. These patterns will be 1) Breathing in through the nose only and out through the mouth only 2) Breathing in through the mouth only and out through the nose only 3) Breathing in and out through the nose only 4) Breathing in and out through the mouth only The data obtained from volunteers and patients will be compared within and between the groups.

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Key information

Conditions

Respiratory Physiology Breathing Patterns Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Massachusetts General Hospital, Respiratory Care Laboratory

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • For healthy subjects:
  • Ten healthy adult (> 18 years of age) volunteers will be recruited from the MGH main campus through intra-hospital e-mail broadcasting. Subjects with the following issues will be excluded from the study.
  • For patients with respiratory insufficiency:
  • Twenty adult (> 18 years of age) patients will be recruited. These patients will be either patients in acute respiratory failure resulting from COPD exacerbation breathing spontaneously only receiving nasal oxygen admitted to the medical floors of the MGH; or patients with diagnosed stable COPD on home oxygen therapy seen by pulmonary physicians in the outpatient clinics or coming to the MGH as study subjects.

Exclusion criteria

  • For healthy volunteers:
  • Subjects with facial deformity, heavy beard or moustache which prevents good seal between the mask and the face;
  • Subjects who have claustrophobia and cannot wear the mask.
  • For patients with respiratory insufficiency:
  • Patients with facial deformity, heavy beard or moustache which prevents a good seal between the mask and the face;
  • Patients who have claustrophobia and cannot wear the mask.
  • Patients who are hemodynamically unstable.
  • Patients requiring continuous noninvasive positive pressure ventilation or endotracheal intubation.

Treatment and study plan

Breathing Patterns

Other

All subjects will breathe in four different breathing patterns which are provided by specific masks. Patterns are as the following:

  • Breathing in through the nose only and out through the mouth only
  • Breathing in through the mouth only and out through the nose only
  • Breathing in and out through the nose only
  • Breathing in and out through the mouth only

Primary outcomes

  1. Determining the anatomic dead space change at variable tidal volumes with four different breathing patterns (nose-in and nose-out, mouth-in and mouth-out, nose-in and mouth-out, mouth-in and nose-out) in healthy volunteers.

    Time frame: 3 months

  2. Comparing the efficiency of CO2 removal at given minute ventilations with the four different breathing patterns in patients with chronic respiratory failure.

    Time frame: 6 months

Secondary outcomes

  1. Comparing the efficiency of the study mask which forces subjects to breathe in a manner similar to pursed lip breathing and a regular facemask in healthy volunteers and patients with respiratory failure

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Registry information

Official study title

Investigation of Efficiency of Breathing With Different Breathing Patterns in Healthy Volunteers and Patients With Respiratory Failure

Important dates

Study start
2007
Primary completion
2011
Study completion
2011
First posted
Nov 3, 2008
Registry last updated
Dec 2, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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