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Completed

NCT Number: NCT06803212

Investigation of Dual-Task Exercise's Effect in Parkinson's Disease

This study was conducted to investigate the effects of dual-task training on upper extremity motor functions in patients with Parkinson's disease. A total of 32 patients participated in the study. Patients were divided into two groups by randomization. One group received only conventional physiotherapy applications, while the other group performed dual-task exercises in addition. Dual-task exercises were performed while conventional treatment was applied. The treatment program was applied as 60x5x6 min/day/week.

Conventional treatment was determined according to the individual needs of the patients, including the lower and upper extremities. Dual-task interventions included performing such as counting backward, word recall, and reading words backward.

Assessments were repeated twice: Baseline and after a 30-session. "Demographic Information", "Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)", "Box and Block Test" and "Parkinson Disease Questionnaire (PDQ-39) were used as assessment tools.

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Key information

Age range

50 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

İstanbul Tıp Merkezi

Istanbul, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 50-85 years with a diagnosis of Stage 1-3 Parkinson's disease, based on the Hoehn & Yahr Scale
  • Patients had to have no issues with performing basic mathematical operations, - A Mini-Mental State Examination (MMSE) score above 24 points,
  • Regular medication use for at least 4 weeks (for patients who were prescribed medical treatment),
  • No comorbid neurological, neuromuscular, or orthopedic diseases

Exclusion criteria

  • Patients with vision or hearing impairments,
  • Moderate-to-severe fluctuations in tremor or dyskinesia,
  • Having deep brain stimulator implants, or sensory loss in the upper extremities.

Treatment and study plan

Conventional Physiotherapy Program

Other

The patients' conventional physiotherapy program included stretching, strengthening, balance, and coordination exercises according to their individual needs

Dual-Task Interference

Other

This intervention consisted of counting backward, reading words backward, and remembering word exercises.

Primary outcomes

  1. Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):

    Time frame: Baseline of the study

    The scale consists of four separate domains. The first section includes non-motor experiences in daily life (13 items), the second section includes motor experiences in daily life (13 items), the third section involves motor examination (33 items), and the last section addresses motor complications (6 items). The scale contains 65 individual items in total. Items are generally scored between 0-4, with some Yes/No items. The domains of the scale directly related to the upper extremities, including eating, dressing, cleaning, writing, rigidity, finger movements, hand movements, pronation and supination of the hand, postural tremor in the hands, kinetic tremor in the hands, resting tremor, and tremor persistence, were used in this study (Figure 1). The MDS-UPDRS scoring was performed while patients were in the "ON" state.

  2. Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):

    Time frame: End of the 30th physiotherapy session

    The scale consists of four separate domains. The first section includes non-motor experiences in daily life (13 items), the second section includes motor experiences in daily life (13 items), the third section involves motor examination (33 items), and the last section addresses motor complications (6 items). The scale contains 65 individual items in total. Items are generally scored between 0-4, with some Yes/No items. The domains of the scale directly related to the upper extremities, including eating, dressing, cleaning, writing, rigidity, finger movements, hand movements, pronation and supination of the hand, postural tremor in the hands, kinetic tremor in the hands, resting tremor, and tremor persistence, were used in this study (Figure 1). The MDS-UPDRS scoring was performed while patients were in the "ON" state.

Secondary outcomes

  1. Box Block Test (BBT)

    Time frame: Baseline of the study

    The BBT consists of a panel and two boxes, one containing 150 wooden blocks. The patient is asked to transfer blocks from one box to another within 60 seconds, one block at a time, using only one hand. The test is repeated with both hands. The number of blocks moved provides the total score. A higher score indicates better manual dexterity.

  2. Box Block Test (BBT)

    Time frame: End of the 30th physiotherapy session

    The BBT consists of a panel and two boxes, one containing 150 wooden blocks. The patient is asked to transfer blocks from one box to another within 60 seconds, one block at a time, using only one hand. The test is repeated with both hands. The number of blocks moved provides the total score. A higher score indicates better manual dexterity.

  3. Parkinson's Disease Questionnaire - 39 (PDQ-39)

    Time frame: Baseline of the study

    This licensed tool assesses the quality of life associated with Parkinson's disease with a total of 39 items. Each item is scored between 0-4, with higher scores indicating poor quality of life. Responses are converted into hundredths for scoring, and the total score ranges from 0 to 100 points.

  4. Parkinson's Disease Questionnaire - 39 (PDQ-39)

    Time frame: End of the 30th physiotherapy session

    This licensed tool assesses the quality of life associated with Parkinson's disease with a total of 39 items. Each item is scored between 0-4, with higher scores indicating poor quality of life. Responses are converted into hundredths for scoring, and the total score ranges from 0 to 100 points.

  5. Demographic Data Form

    Time frame: Baseline of the study

    This form was developed by the investigators and included age, body mass index, disease duration, sex, dominant limb, education level, presence of freezing, presence of tremor, MMSE score, total daily dose of levodopa, and Hoehn & Yahr Staging.

Sponsors and collaborators

Lead sponsor

Emre Şenocak

Other

Registry information

Official study title

Effect of Dual-Task Interference on Upper Extremity Motor Experience With Parkinson's Disease

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jan 31, 2025
Registry last updated
Jan 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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