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OpenTrials
Completed

NCT Number: NCT02616835

Investigating the Physiology of Targeted Theta-burst Neuromodulation

This research seeks to study the physiological effects of theta-burst transcranial magnetic stimulation (TMS) in the brains of healthy controls using functional MRI and spectroscopy.

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Key information

Conditions

Healthy Volunteers

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sarina Iwabuchi

Nottingham, Nottinghamshire, NG7 2TU, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • No personal history of neurological or psychiatric disorders

Exclusion criteria

  • Have had a brain injury or neurological disorder
  • Have ever suffered an epileptic fit
  • Have any non-removable metal implants
  • Drink more than 20 units of alcohol per week on a regular basis
  • Currently take any illicit drugs on regular basis
  • Likely to be pregnant
  • Ever suffered from a serious mental illness such as schizophrenia, severe depression or bipolar disorder
  • Currently take any psychotropic medication

Treatment and study plan

theta-burst TMS

Device

This protocol involves short periods of pulse delivery in combination with long periods of silent intervals.

sham theta-burst TMS

Device

This protocol delivers theta-burst pulses from a sham device (i.e. at same speed and timeframe but without the magnetic output)

Primary outcomes

  1. Changes in functional connectivity following TMS administration using functional MRI

    Time frame: One hour

    Changes in brain connectivity will be assessed by comparing functional MRI scans after theta-burst TMS and sham theta-burst TMS

Secondary outcomes

  1. Changes in brain metabolites following TMS administration using MR spectroscopy

    Time frame: One hour

    Using MRI scans, changes in metabolites in the brain will be assessed following theta-burst TMS and sham TMS

Sponsors and collaborators

Lead sponsor

Institute of Mental Health Nottingham

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Nov 30, 2015
Registry last updated
Nov 30, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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