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Completed

NCT Number: NCT05404841

Investigating the Effect of Whole-fruit Coffee Extract on Exercise Performance

Caffeine is a widely used efficacious supplement by both the general public, and athletes, with the goal of improving performance. The effects of caffeine alone are well known, but it is not clear whether a multi-ingredient supplement (containing both caffeine and polyphenols) can affect exercise performance.

This study aims to determine if a low dose of caffeine, in the form of a whole-fruit coffee extract also containing polyphenols, can improve exercise performance compared to a placebo condition, with a secondary objective of identifying if this supplement can improve post exercise refuelling (glycogen resynthesis).

Participants will consume either the supplement or a placebo before engaging in an exercise protocol. Muscle biopsies will then be obtained so as to measure subsequent glycogen resynthesis, with multiple blood samples being taken through the day. The following morning another biopsy will be taken before the exercise protocol will be repeated.

This research will inform us of the efficacy of caffeine and polyphenols on improving exercise performance.

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Key information

Conditions

Caffine and Endurance Performance

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sport & Health Sciences University of Exeter, Exeter, Devon, United Kingdom

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Exclusion criteria

  • Allergy to Lidocaine
  • Exclusion critera
  • Any diagnosed metabolic health condition
  • Pregnant
  • Non-habitual caffeine intake
  • Smoker
  • No endurance training
  • Diagnosed Cardiovascular disease
  • Beta-Blockers
  • Recent history of musculoskeletal injury

Inclusion criteria

  • Age 18-40
  • Heathy
  • Highly trained endurance athletes (V̇O2max: males >55 and females >50 mL⋅kg bm-1⋅min-1)
  • Both males and females are allowed to participate. If females are on the oral contraceptive pill they are to be tested on consecutive weeks. If they are not on the oral contraceptive pill, then female subjects are to be tested every 4 weeks, at the same point of their menstrual cycle.

Treatment and study plan

CoffeeBerry Supplement

Dietary Supplement

A Coffeeberry supplement containing 200mg Caffeine and 14mg polyphenols, manufactured by FutureCeuticals Inc.,

Placebo

Dietary Supplement

Placebo

Primary outcomes

  1. Exercise performance

    Time frame: 15 Minitues

    Amount of work completed in 15 minutes

Secondary outcomes

  1. Glycogen Resynthesis

    Time frame: 24 Hours

    The diffrence in glycogen within the muscle between two time points

  2. Alertness

    Time frame: 1 Minitue

    10 cm visual analog scale (Ranging from Not Alert to Extremly Alert)

  3. Motivation

    Time frame: 1 Minitue

    10 cm visual analog scale (Ranging from Not motivated to Extremly motivated)

  4. Rate of perceived exertion

    Time frame: 1 Minitue

    Validated Borg scale (6-20 Arbitrary units)

  5. Urine osmolarity

    Time frame: 24 Hours

    The hydration status of the individual measured in mOsmo|/kg

  6. GI comfort

    Time frame: 1 Minitue

    10 cm visual analog scale (Ranging from No discomfort to Extreme discomfort)

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Collaborators

  • VDF FutureCeuticals Inc.

Registry information

Acronym: PACE

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jun 3, 2022
Registry last updated
Mar 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.