University of Exeter
Exeter, Devon, EX1 2LU, United Kingdom
Completed
NCT Number: NCT04794153
Investigating the Consumption of Different Protein Rich Whole Food Sources on Muscle Growth in Trained Males and Females
Background To date, most of the literature investigating the role of dietary protein in muscle growth has focused on isolated protein sources. However, dietary protein is most commonly consumed within a whole food source. Consuming dietary protein within a whole food matrix may additionally stimulate muscle growth. The idea being, there may be other components within food, capable of producing a greater response.
Objectives: To assess the effect of consuming a variety of whole food sources, on the stimulation of muscle growth compared to an isolated protein source following a single bout of lower body resistance exercise.
Methods Young healthy resistance-trained volunteers will consume a protein rich whole food source, following a bout of lower body resistance exercise. Stable isotope IV infusions and repeated blood and muscle samples will be taken to assess protein digestion and absorption, as well as muscle protein synthesis rates.
Value of Research:
To determine whether whole food sources potentiate muscle protein synthesis rates (and to what extent across whole food sources) compared to an isolated protein source. In doing so, we can further investigate the nutrients involved that may be contributing to this effect.
Completed
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Notify MeKey information
Age range
18 year–40 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Males and Females
- BMI 18.5 - 30 kg/m2
- Aged 18 - 40 years
- Structured Resistance training consistently for > 6 months
- A 5-7 day "washout" period from any supplementation
Exclusion criteria
- Age >40 years
- Body mass index (BMI) <18.5 or >30 kg/m2
- Any metabolic impairments
- Any cardiovascular impairments
- High blood pressure (≥140/90 mmHg)
- Any gastrointestinal disorders
- Any medications known to affect protein and/or amino acid metabolism
- A personal or family history of epilepsy, seizures or schizophrenia, motor disorder
- Chronic over the counter use of pharmaceuticals (> 1 month)
- Allergic to any of the whole foods included in the study
Treatment and study plan
whole food sources
Dietary SupplementFoods selected are naturally high in protein and consumed by the general population as part of a meal.
Primary outcomes
-
Postprandial Muscle protein Synthetic Response following the ingestion of a protein rich whole food source.
Time frame: 2 years
84 participants will undergo a single bout of lower body exercise followed by the ingestion of one of the six protein rich whole food sources. Using stable isotope tracer methodology and muscle biopsy samples, the postprandial muscle protein synthetic response will be able to be calculated.
Sponsors and collaborators
Lead sponsor
University of Exeter
Other
Collaborators
- Marlow Foods Ltd
Registry information
Official study title
Assessing the Muscle Protein Synthetic Response Following the Ingestion of a Variety of Protein Rich Whole Foods Compared to an Isolated Protein Source.
Acronym: FFT
Important dates
- Study start
- 2021
- Primary completion
- 2024
- Study completion
- 2024
- First posted
- Mar 11, 2021
- Registry last updated
- May 9, 2024
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.