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NCT Number: NCT07184723

Investigating Practice Patterns in Symptomatic Non-ruptured Abdominal Aortic Aneurysms (AAA) in Europe

Symptomatic non-ruptured abdominal aortic aneurysms (snrAAA) remain a clinical challenge due to limited evidence and heterogeneous definitions and management strategies. Unlike ruptured AAAs, snrAAA lack large-scale population-based studies, primarily due to inconsistent application of standardised medical classifications (e.g., ICD-10) and international variability in definitions, diagnostic approaches, and treatment protocols. Optimal diagnostic pathways, preoperative risk assessments, and treatment strategies remain poorly defined, with minimal guidance from existing guidelines.

This study aims to conduct a multinational cross-sectional online survey with optional retrospective validation to assess current opinions on an institutional scale regarding the definition and management of patients with snrAAA in Europe. All European vascular centres offering elective and emergency AAA repair are eligible to participate. Multiple survey entries from the same institution are not allowed. Centres are also invited to participate in a retrospective observational validation, reporting diagnostic and therapeutic details of their last five snrAAA cases.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Vascular and Endovascular Surgery, Clinic Ottakring

Vienna, State of Vienna, 1160, Austria

Location status: Recruiting

Location contact

Afshin Assadian, MD

CONTACT

[email protected]

+43 1 49150 4110

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Last 5 patients (aged >18 years) treated at a participating centre for symptomatic non-ruptured AAA (or the last patients in the preceding 5 years if they have treated less than 5 patients in 5 years)

Exclusion criteria

  • None

Treatment and study plan

Primary outcomes

  1. Number of participants that define non-ruptured symptomatic AAA on clinical symptoms alone assessed by the snrAAA Questionaire

    Time frame: From August 2024 to June 2026

    The objective of this study is to provide insights into current practice strategies in the definition, diagnosis, preoperative optimization, and surgical care of patients with non-ruptured symptomatic AAA in Europe.

    Primary outcome measures will be count and proportion.

Secondary outcomes

  1. Number of participants where the stated practices align with actual treatment patterns assessed by the snrAAA Questionaire and electronic Case Report Form

    Time frame: From August 2024 to June 2026

    In order to validate the data collected on the institutional standard of care for symptomatic non-ruptured AAA cases, centres are kindly invited to participate in a retrospective observational analysis in which they are asked to report the diagnostic and therapeutic procedure of the last 5 patients treated at their institution for symptomatic non-ruptured AAA (or the last patients in the preceding 5 years if they have treated less than 5 patients in 5 years).

    Secondary outcome measures will be count and proportion.

Study contacts

Contact information is provided by the study sponsor or research team.

Amun Georg Hofmann, MD

CONTACT

[email protected]

+43 1 49150 4110

Maria Elisabeth Leinweber, MD

CONTACT

[email protected]

+43 1 49150 4110

Sponsors and collaborators

Lead sponsor

Wilhelminenspital Vienna

Other

Registry information

Acronym: DETHINE

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Sep 22, 2025
Registry last updated
Sep 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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