Skip to main content
OpenTrials
Completed

NCT Number: NCT00870259

Investigating Physiological Adaptations to Weight Loss

The purpose of this study is to examine the effect of diet-induced weight loss on the levels of circulating nutrients and hormones which are involved in feelings of hunger and satiety.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Obesity Body Weight Body Weight Changes Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Weight Loss

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Heidelberg Repatriation Hospital

Melbourne, Victoria, 3081, Australia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • males and post-menopausal females
  • aged over 18 years
  • BMI 27-40kg/m2
  • weight-stable

Exclusion criteria

  • major comorbid medial condition (including diabetes)
  • taking medications known to affect weight
  • smoking

Treatment and study plan

Optifast VLCD

Dietary Supplement

Meal replacement, three times daily for 8 weeks

Primary outcomes

  1. Difference in fasting and/or post-prandial hormone levels following weight loss and after weight maintenance compared with baseline

    Time frame: 2, 6 and 12 months

Secondary outcomes

  1. Difference in fasting and/or post-prandial hormone levels in ketotic compared with non-ketotic state

    Time frame: week 8 vs week 10

  2. Correlation of fasting and post-prandial hormone levels with ratings of hunger and satiety

    Time frame: 0, 2, 6 and 12 months

  3. Association of psychosocial factors with successful weight maintenance

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

University of Melbourne

Other

Registry information

Official study title

An Investigation of Physiological Adaptations Contributing to Weight Regain After Weight Loss

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Mar 27, 2009
Registry last updated
Dec 5, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.