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Completed

NCT Number: NCT04507399

Investigating Consumers Perception and Acceptance of Whey Beverages

Brief Summary: This study aims to investigate whether protein fortification of beverages causes mouthdrying and mucoadhesion and whether this is influenced by saliva flow.

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Key information

Conditions

Individual Difference Behavior Feeding Behavior Food Intolerance Food Preferences Food Sensitivity Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sensory Science Centre, Department of Food and Nutritional Science, University of Reading, Reading, Berkshire, United Kingdom

Reading, RG66UR, United Kingdom

About this study

To investigate whether whey protein beverages causes mouthdrying and reduces acceptability compared with a control beverage (whey permeate beverage) and to determine whether manipulating salivary flow rates influences mouthdrying.

To determine whether mucoadhesion is a probable cause of mouthdrying.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • No food allergies or intolerances
  • Non smokers

Exclusion criteria

  • Taking prescribed medication that could influence study outcomes (such as saliva flow)
  • Relevant food allergies or intolerances
  • Outside age criteria
  • Cancer
  • Had oral surgery or a stroke
  • Smoker
  • Diabetic
  • Anyone who currently has COVID-19 symptoms or who has had COVID-19 within the last 4 weeks

Treatment and study plan

Liquid Model

Behavioral

To study the perception of whey beverages using sensory methods (rating drying as well as discrimination tests "which is the stronger in drying")

Measuring mucoadhesion via protein content remaining in saliva following swallowing of whey protein and whey permeate beverages.

Primary outcomes

  1. Mucoadhesion and Mouthdrying

    Time frame: Saliva collection and mouthdrying scoring throughout visits, 2 days

    Following swallowing of different whey beverage samples (whey protein / whey permeate), volunteers will be asked either to rate samples for mouthdrying or to spit their saliva into a tube at specific timepoints (15s & 60s) with appropriate rest periods. The rating and spitting times will be set within a balanced order protocol.

Secondary outcomes

  1. Mouthdrying from whey beverages

    Time frame: 1 day (Sampled at study visit one)

    Perceived mouth drying from whey beverages (whey permeate / whey protein) using data from sensory methods (rating drying as well as discrimination tests "which is the stronger in drying"). Scale for scoring is the gLMS scale (general linear magnitude scale); higher value is worse outcome.

  2. Manipulating saliva flow and mouthdrying from whey beverages

    Time frame: 1 day (Sampled at study visit one)

    Volunteers will be asked to manipulate their saliva flow and consume whey beverages (whey permeate / whey protein) and score perceived mouth drying (data will be collected from sensory methods (rating drying as well as discrimination tests "which is the stronger in drying")

  3. Saliva collection

    Time frame: 1 day (Sampled at study visit two)

    Salivary flow rates from unstimulated and stimulated saliva samples.

Sponsors and collaborators

Lead sponsor

University of Reading

Other

Registry information

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Aug 11, 2020
Registry last updated
Mar 12, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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