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OpenTrials
Completed

NCT Number: NCT01935791

Investigating Brown Adipose Tissue Activation in Humans

The purpose of this study is to determine what can activate brown adipose tissue (BAT).

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Key information

Conditions

Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Imperial College London

London, United Kingdom

About this study

We will investigate different stimuli (i.e. hormones) to determine which can stimulate BAT.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged >18 years

Exclusion criteria

  • medical conditions
  • recreational drug use
  • participation in other trials within the preceding 2 months
  • blood donation within 3 months of study participation

Treatment and study plan

Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Vehicle

Other

Temperature

Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Glucagon

Drug

Hormone

Period 1 Visit 1 - Cold PET-CT Vehicle, no visit 2 as BAT negative

Other

Temperature

Period 2 - Visit 1 Warm Control vehicle, Visit 2 Warm Glucagon, Visit 3 Cold control

Drug

Hormone

Period 2 - Visit 1 Warm Glucagon, Visit 2 Cold control , Visit 3 Warm control

Drug

Hormone

Period 2 -Visit 1 cold control, Visit 2 warm control, Visit 3 Warm glucagon

Drug

hormone

Period 2 -Visit 1 cold control, visit 2 warm glucagon, visit 3 warm control

Drug

hormone

Period 2- Visit 1 Warm glucagon, visit 2 warm control, visit 3 cold control

Drug

hormone

Period 2 - Visit 1 Warm control, visit 2 cold control, visit 3 warm glucagon

Drug

Hormone

Primary outcomes

  1. Brown Adipose Tissue Activation Following Glucagon or Saline Infusion

    Time frame: 2hours

    Period 1 Brown Adipose Tissue (BAT) activation measured using metabolic rate of glucose (MR[gluc]) during F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET-CT) for Cold PET-CT Vehicle vs Warm PET-CT Vehicle vs warm PET-CT Glucagon.

  2. Increase in Energy Expenditure Following Glucagon or Saline Infusion

    Time frame: 2hours

    Period 2 Increase in energy expenditure measured using indirect calorimetry for Cold control vs Warm Control vs Warm Glucagon.

Sponsors and collaborators

Lead sponsor

Imperial College London

Other

Registry information

Important dates

Study start
2013
Primary completion
2018
Study completion
2018
First posted
Sep 5, 2013
Registry last updated
May 18, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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