Investigating a Model for Acute Ischemic Pain in Humans

The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies. The investigators examined whether peripheral nerve damage and acute inflammation occur during short episodes of acute ischemia.

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Key information

Conditions

Peripheral Arterial Disease Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Cardiovascular Diseases Peripheral Vascular Diseases Vascular Diseases

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Munich, Pettenkoferstr. 8a

Munich, 80336, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients over 40 years
unilateral femoral-popliteal PAD, Fontaine grade II

Exclusion criteria

patients with pain at rest or other pain origin
diabetic polyneuropathy
deep vein thrombosis

Treatment and study plan

acute ischemic pain

Other

acute ischemic pain was induced by treadmill exercise

Primary outcomes

Induce acute ischemic pain

Time frame: during treadmill exercise (less than 15 minutes)

To induce acute ischemic pain, patients performed treadmill exercise until intolerable pain developed.

Sponsors and collaborators

Lead sponsor

Ludwig-Maximilians - University of Munich

Other

Registry information

Important dates

Study start: 2007
Primary completion: 2008
Study completion: 2008
First posted: Jul 16, 2014
Registry last updated: Jul 16, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed