Service Anesthésie Réanimation Chirurgicale Hôpital Cochin
Paris, 75014, France
Completed
NCT Number: NCT04808440
Intubation Conditions With Atracurium After Three Minutes
The purpose of this study is to evaluate intubation conditions with the use of atracurium after a fixed three-minute delay
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Conditions
Age range
18 year and older
Sex eligibility
Female
Study type
Observational
Primary location
About this study
The recommended dose of a non-depolarizing curare to facilitate tracheal intubation is twice the active dose 95 (the dose that reduces muscle force by 95%). At this dosage, curarization of the laryngeal adductors allowing relaxation and abduction (opening) of the vocal cords is considered certain. With atracurium, the dose for intubation is 0.5 mg.kg-1 and the time to full effect is approximately 3 minutes. With the use of newer hypnotics, there are no data evaluating the conditions for intubation after a fixed time of 3 minutes as with current anesthetic practices.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Adult female
- Patient to undergo general anesthesia with intubation for scheduled gynecological surgery
- Patient informed about the study and not opposed to it
Exclusion criteria
- Patients with severe and morbid obesity (BMI>35kg/m2)
- Pregnancy
- Patients with difficult intubation
- Allergy to atracurium and to any other drug used.
- Patient under tutorship / curatorship
- Not affiliated with social insurance
- Patient with AME
Treatment and study plan
Primary outcomes
-
Intubation condition
Time frame: 3 minutes after atracurium injection
The intubating conditions were evaluated on the basis of the consensus conference on Good Clinical Research Practice in Pharmacodynamic Studies of Neuromuscular Blocking Agents. The score used include the following variables: (1) ease of laryngoscopy, (2) vocal cord position, and (3) reaction to the insertion of the endotracheal tube and the cuff inflation (eg, diaphragmatic movement due to patient cough). Each of these variables was rated as (1) excellent, (2) good, or (3) poor. Intubating conditions were scored as excellent if all variables were excellent; the score was good if at least 1 variable was good and the rest were excellent; the conditions were considered poor if any of the variables was rated poor.
Evaluation of intubation conditions with the use of atracurium after a fixed three-minute delay
Sponsors and collaborators
Lead sponsor
Assistance Publique - Hôpitaux de Paris
Other
Collaborators
- URC-CIC Paris Descartes Necker Cochin
Registry information
Official study title
Evaluation of Intubation Conditions With the Use of Atracurium After a Fixed Three-minute Delay
Acronym: CINTROI
Important dates
- Study start
- 2021
- Primary completion
- 2021
- Study completion
- 2021
- First posted
- Mar 22, 2021
- Registry last updated
- Sep 12, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.