Intravenous/Subcutaneous FIH Study of REGN1154 in Healthy Volunteers

Inclusion criteria

• Healthy men and women between the ages of 18 and 65; women must be postmenopausal or surgically sterile
• Body mass index (BMI) between 18.0 and 30.0 kg/m2, inclusive
• Willing, committed, and able to return for ALL clinic visits and complete all study-related procedures
• Able to read or to understand the consent process, and willing to sign the informed consent form (ICF)

Exclusion criteria

Exclusion criteria

include, but are not limited to the following:

• Any illness or condition that would adversely affect the subject's participation in this study
• Any clinically significant abnormalities observed during the screening visit
• Use of certain medications taken before the screening visit
• Onset of a new exercise routine or major change to a previous exercise routine within 4 weeks prior to screening visit
• Hospitalization within 60 days of the screening visit
• Any condition that would place the subject at risk, interfere with participation in the study
• History of or positive human immunodeficiency virus (HIV) screen result at the screening visit
• History of certain other conditions
• Positive urine, drug or alcohol screen result at screening
• Known sensitivity to any of the components of the investigational product formulation
• Participation in any clinical research study evaluating another investigational drug or therapy within 30 days or at least 5 half-lives (whichever is longer), of the investigational drug prior to the screening visit
• Live/attenuated vaccinations within 12 weeks of screening or during the study