Intravenous Lidocaine for Postoperative Fatigue After Laparoscopic TAPP Inguinal Hernia Repair

Postoperative fatigue syndrome is a common problem after surgery and may negatively affect recovery quality, mobilization, and patient satisfaction. Intravenous lidocaine has anti-inflammatory, antihyperalgesic, and opioid-sparing properties that may improve postoperative recovery outcomes.

This prospective randomized controlled trial will include adult patients undergoing elective laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair under general anesthesia. Eligible participants will be randomly allocated into two groups. The lidocaine group will receive perioperative intravenous lidocaine infusion according to the study protocol, while the control group will receive standard perioperative care without lidocaine infusion.

The primary outcome of the study is postoperative fatigue syndrome. Secondary outcomes include postoperative pain scores, opioid consumption, postoperative nausea and vomiting, time to mobilization, and duration of hospital stay.

The study is designed as an investigator-initiated academic clinical trial conducted at a tertiary training and research hospital in Türkiye.

Inclusion criteria

Adult patients aged 18 years and older Patients scheduled for elective laparoscopic TAPP inguinal hernia repair under general anesthesia ASA physical status I-II Patients who provide written informed consent -

Exclusion criteria

Moderate to severe hepatic dysfunction Low cardiac output or severe heart failure Severe cardiac conduction abnormalities or clinically significant arrhythmias Planned concomitant use of high-dose local anesthetics, including infiltration or regional block Advanced age or frailty Pregnancy or breastfeeding Known allergy or contraindication to lidocaine Refusal to participate in the study

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