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NCT Number: NCT05750264

Intravenous Ibuprofen Postoperative Analgesia After Abdominal Hysterectomy

The current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Post Operative Analgesia

Age range

18 year–80 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2

Primary location

Faculty of Medicine

Cairo, Shebin Elkom, Egypt

About this study

The patients will be given general anaesthesia. Anaesthesia will be induced by propofol 1-2 mg/kg, and fentanyl 1-2 µg/kg. Endotracheal intubation will be facilitated by atracurium 0.5 mg/kg. Anaesthesia will be maintained by isoflurane in oxygen - air mixture. Transversus abdominis plane block will be performed at the end of the operation. A postoperative analgesic regimen according to group allocation will be started.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of anaesthesiologists physical status I to III.
  • Open abdominal hysterectomy operations

Exclusion criteria

  • History of gastrointestinal bleeding.
  • History of intracranial haemorrhage.
  • Pregnancy and lactation.
  • Taking angiotensin converting enzyme(ACE) inhibitors or anticoagulation drugs.
  • Asthmatic, hepatic,renal or heart failure.
  • Abnormal platelet count.

Treatment and study plan

Ibuprofen

Drug

800 mg of IV ibuprofen

Primary outcomes

  1. Morphine consumption

    Time frame: Postoperative up to 24 hours

    mg

Secondary outcomes

  1. Pain intensity

    Time frame: Postoperative up to 24 hours

    Visual analogue score: a score from 0 to 10( 0= no pain and 10 the worst imaginable pain)

  2. Anaesthesia recovery time

    Time frame: Perioperative

    Minutes

  3. Duration of post anaesthesia care unit stay

    Time frame: First postoperative 24 hours

    Minutes

  4. Time of first ambulation

    Time frame: First postoperative 24 hours

    Minutes

  5. Duration of hospital stay

    Time frame: Postoperative up to 4 weeks

    Days

  6. Heart rate

    Time frame: Perioperative

    Beats/minute

  7. Mean arterial blood pressure

    Time frame: Perioperative

    mmHg

  8. Arterial oxygen saturation

    Time frame: Perioperative

    Percentage

  9. End tidal carbon dioxide

    Time frame: Perioperative

    mmHg

  10. Respiratory rate

    Time frame: Perioperative

    Breath/minute

Sponsors and collaborators

Lead sponsor

Menoufia University

Other

Registry information

Official study title

Efficacy of Intravenous Ibuprofen in Multimodal Pain Management After Open Abdominal Hysterectomy: A Randomised Trial

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Mar 1, 2023
Registry last updated
May 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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