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Completed

NCT Number: NCT07701187

Intravenous Anesthesıa and Cognıtıve Functıon ın Spınal Surgery

The aim of this study is to investigate the effect of these two different intravenous infusion techniques [manuel controlled infusion (MCI) and Target controlled Infusion( TCI)] on POCD. To assess POCD, the Mini Mental State Examination (MMSE ) and the Montreal Cognitive Assessment (MoCA ) will be used. MoCA and MMSE have high sensitivity and specificity for identifying patients with mild cognitive impairment who perform within the normal range. In a study by Meng et al., comparing target-controlled infusion and manual infusion of propofol anesthesia during electroconvulsive therapy, the randomized, controlled trial showed no significant difference in postelectroconvulsive therapy changes in MoCA scores in either group; however, they reported improvement in MoCA scores after 6 electroconvulsive therapy treatments in the MCI group, while deterioration occurred in the TCI group. Researchers found no studies investigating the effects of both infusion methods in spinal surgery and their impact on cognitive function, and they planned to evaluate the effects of the groups in their study.

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Key information

Conditions

Postoperative Cognitive Dysfunction (POCD) Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Cognitive Complications Postoperative Complications

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bursa yüksek ihtisas eğitim ve araştırma hastanesi BURSA, Bursa, Türkiye, BURSA, Bursa 16310, BURSA, Bursa

Bursa, 16310, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Turkish language proficiency,
  • age (18-65 years),
  • American Society of Anesthesiologists (ASA) I-III score,
  • elective spinal surgery.

Exclusion criteria

  • - refusal to participate
  • central nervous system disorders,
  • use of antidepressants or antipsychotic medications,
  • alcohol or drug use,
  • illiteracy.

Treatment and study plan

Manuel controlled infusion group

Device

infusion via manually controlled infusion pumps

Other names: MCI

Primary outcomes

  1. Post-Operative Cognitive Dysfunction

    Time frame: preoperatively and 24 hours postoperatively at the patient's bedside

    Montreal Cognitive Assessment (MoCA) scores

    Normally accepted threshold values:

    A score of 26 or higher on the MoCA (Montreal Cognitive Assessment) test

    For cognitive impairment:

    A decrease of at least 1-2 points on the MoCA is considered significant.

Secondary outcomes

  1. Evaluation of intraoperative anaesthezic consumption

    Time frame: intraoperatıve

    total propofol and total remifentanil

Sponsors and collaborators

Lead sponsor

Bursa Yuksek Ihtisas Training and Research Hospital

Other Gov

Registry information

Official study title

The Effect of Two Dıfferent Intravenous Anesthesıa Technıques on Cognıtıve Functıons ın Spınal Surgery

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jul 14, 2026
Registry last updated
Jul 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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