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Completed

NCT Number: NCT00695045

Intrathecal Morphine in Knee Arthroplasty

This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

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Key information

Conditions

Pain, Postoperative Arthroplasty, Replacement, Knee Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients for elective total knee arthroplasty

Exclusion criteria

  • No contraindication to spinal
  • No allergy to morphine, rescue analgesia or anti-emesis treatment.

Treatment and study plan

intra thecal morphine

Drug

100 mcg intrathecal morphine given once .

Other names: intraspinal morphine

Primary outcomes

  1. pain

    Time frame: 24 hours

Secondary outcomes

  1. nausea and vomiting

    Time frame: 24 hours

  2. pruritus

    Time frame: 24 hours

  3. sedation

    Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

University College Hospital Galway

Other

Registry information

Official study title

Determination of the Efficacy and Side-Effect Profile of Lower Doses of Intrathecal Morphine in Patients Undergoing Total Knee Arthroplasty

Important dates

Study start
2003
Primary completion
2007
Study completion
2007
First posted
Jun 11, 2008
Registry last updated
Jun 11, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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