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OpenTrials
Completed

NCT Number: NCT03387956

Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting

optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting. Dexamethasone, and or atropine could offer some protection against nausea and vomiting.

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Key information

Conditions

Postoperative Nausea Nausea Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Nausea and Vomiting Signs and Symptoms Signs and Symptoms, Digestive Vomiting

Age range

20 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Emad Zarief Kamel Said

Asyut, 71111, Egypt

About this study

One of the gold standards for analgesia following cesarean delivery is intrathecal morphine, which is not devoid of complications namely postoperative nausea and vomiting. We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after cesarean delivery under spinal bupivacaine plus morphine anesthesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • females
  • 18-40 years of age
  • elective cesarean delivery under bupivacaine spinal anesthesia

Exclusion criteria

  • renal disease
  • preeclampsia
  • liver disease
  • cardiac disease
  • Coagulopathy
  • chronic cough
  • nausea
  • vomiting
  • patient refusal

Treatment and study plan

Intrathecal atropine

Drug

100ug intrathecal atropine will be injected with spinal anesthesia

Dexamethasone

Drug

intravenous 8 mg dexamethasone (2ml).

Primary outcomes

  1. postoperative nausea

    Time frame: 24 hours

    Monitoring scale of nausea and vomiting

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Intravenous Dexamethasone Combined With Intrathecal Atropine to Prevent Morphine-related Nausea and Vomiting After Cesarean Delivery: A Randomized Double-blinded Study

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Jan 2, 2018
Registry last updated
Jun 6, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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